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Study Information
Study Attribute Value
CEBS Accession Number: 002-02318-0011-0000-8
Chemical Name: Isophorone
CASRN: 78-59-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 783723_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
06/27/1990 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
50         
 11170 50 45 9 0 0 0 0 0 54 1.08 0.90 30.00 22.00
    11171 50 11 5 0 0 0 0 0 16 0.32 0.22 26.00 18.00
    11172 50 41 12 0 0 0 0 0 53 1.06 0.82 32.00 24.00
    11173 50 58 14 1 1 0 0 0 74 1.48 1.18 38.00 30.00
    11174 50 36 10 0 0 0 2 0 48 0.96 0.76 22.00 12.00
    11175 50 19 4 1 0 0 1 0 25 0.50 0.42 14.00 10.00
    11176 50 35 8 0 0 0 0 0 43 0.86 0.70 24.00 16.00
    11177 50 35 4 1 0 0 0 0 40 0.80 0.72 30.00 24.00
Average         35.0 8.3 0.4 0.1 0.0 0.4 0.0 44.1 0.88 0.72 27.00 19.50
± SEM                         0.13 0.10 2.56 2.38
 
Test Chemical Isophorone 
125         
 11100 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11101 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11102 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11103 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 4.00
    11104 50 1 0 0 0 0 1 0 2 0.04 0.04 4.00 4.00
    11105 50 3 1 0 0 0 1 0 5 0.10 0.08 10.00 8.00
    11106 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11107 50 2 4 0 0 0 0 0 6 0.12 0.04 10.00 4.00
Average         1.3 1.1 0.0 0.0 0.0 0.3 0.0 2.6 0.05 0.03 4.75 3.00
± SEM                         0.02 0.01 1.31 0.93
 
Test Chemical Isophorone 
250         
 11110 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11111 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    11112 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11113 50 1 3 0 0 0 1 0 5 0.10 0.04 10.00 4.00
    11114 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    11116 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11117 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11118 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         0.8 1.0 0.0 0.0 0.0 0.1 0.0 1.9 0.04 0.02 3.75 1.75
± SEM                         0.01 0.01 1.33 0.70
 
Test Chemical Isophorone 
500         
 11120 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11121 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11122 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    11123 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    11124 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11125 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    11126 50 1 1 0 0 0 0 0 2 0.04 0.02 2.00 2.00
    11127 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         1.0 0.8 0.0 0.0 0.0 0.0 0.0 1.8 0.04 0.02 3.25 2.00
± SEM                         0.01 0.01 0.53 0.76
 
Vehicle Control No Stressor 
 0         
 11160 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11161 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
    11162 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11163 50 0 3 0 0 0 0 0 3 0.06 0.00 4.00 0.00
    11164 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    11165 50 2 1 1 0 0 0 0 4 0.08 0.06 8.00 6.00
    11166 50 1 0 1 0 0 0 0 2 0.04 0.04 2.00 2.00
    11167 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.3 0.5 0.3 0.0 0.0 0.0 0.0 2.0 0.04 0.03 3.50 2.75
± SEM                         0.01 0.01 1.12 1.06
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation