Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02806-0007-0000-5 |
Chemical Name: | Sodium (2-ethylhexyl)alcohol sulfate |
CASRN: | 126-92-1 |
NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
NTP Study ID: | 795640_CA |
Study Result: | Negative |
Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.
Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Result |
---|---|---|---|---|---|---|---|
12/13/1988 | Bone Marrow | 17 | Male | Mouse | B6C3F1 | Intraperitoneal Injection x 1/study, 17 hour | Negative |
Dose (mg/kg) |
Animal Number |
No. Cells |
Chromatid | Isochromatid | Exchanges | Aberrations | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Breaks | Gaps | Breaks | Gaps | 'Tid | 'Some | Other | Total | Per Cell | % Cells w/ Abs | |||||||
(+ Gaps) | (- Gaps) | (+ Gaps) | (- Gaps) | |||||||||||||
Positive Control | Mitomycin-C |
1 |
9288 | 50 | 9 | 3 | 0 | 0 | 0 | 0 | 1 | 13 | 0.26 | 0.20 | 22.00 | 18.00 |
9289 | 50 | 20 | 6 | 0 | 0 | 0 | 0 | 0 | 26 | 0.52 | 0.40 | 24.00 | 20.00 | |||
9290 | 50 | 35 | 5 | 1 | 0 | 0 | 0 | 1 | 42 | 0.84 | 0.74 | 38.00 | 30.00 | |||
9291 | 50 | 22 | 4 | 0 | 0 | 0 | 0 | 0 | 26 | 0.52 | 0.44 | 30.00 | 22.00 | |||
9292 | 50 | 1 | 2 | 0 | 1 | 0 | 0 | 0 | 4 | 0.08 | 0.02 | 8.00 | 2.00 | |||
9293 | 50 | 23 | 3 | 0 | 0 | 0 | 0 | 1 | 27 | 0.54 | 0.48 | 32.00 | 26.00 | |||
9294 | 50 | 18 | 1 | 0 | 0 | 0 | 0 | 1 | 20 | 0.40 | 0.38 | 26.00 | 26.00 | |||
9295 | 50 | 41 | 3 | 2 | 0 | 0 | 0 | 2 | 48 | 0.96 | 0.90 | 38.00 | 32.00 | |||
Average | 21.1 | 3.4 | 0.4 | 0.1 | 0.0 | 0.0 | 0.8 | 25.8 | 0.52 | 0.45 | 27.25 | 22.00 | ||||
± SEM | 0.10 | 0.10 | 3.46 | 3.32 | ||||||||||||
Test Chemical | Sodium (2-ethylhexyl)alcohol sulfate |
275 |
9248 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 |
9249 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
9250 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.00 | 2.00 | 0.00 | |||
9251 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
9252 | 50 | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 5 | 0.10 | 0.04 | 10.00 | 4.00 | |||
9253 | 50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.02 | 4.00 | 2.00 | |||
9254 | 50 | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 5 | 0.10 | 0.08 | 10.00 | 8.00 | |||
9255 | 50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.02 | 4.00 | 2.00 | |||
Average | 1.1 | 0.9 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.04 | 0.02 | 4.00 | 2.25 | ||||
± SEM | 0.01 | 0.01 | 1.41 | 0.96 | ||||||||||||
Test Chemical | Sodium (2-ethylhexyl)alcohol sulfate |
550 |
9258 | 50 | 6 | 7 | 0 | 0 | 0 | 0 | 0 | 13 | 0.26 | 0.12 | 20.00 | 12.00 |
9260 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
9261 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
9262 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
9263 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
9264 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
9265 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
9267 | 50 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.00 | 4.00 | 0.00 | |||
Average | 1.0 | 1.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.1 | 0.04 | 0.02 | 3.50 | 2.00 | ||||
± SEM | 0.03 | 0.01 | 2.41 | 1.46 | ||||||||||||
Test Chemical | Sodium (2-ethylhexyl)alcohol sulfate |
1100 |
9268 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 |
9269 | 50 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.06 | 6.00 | 6.00 | |||
9270 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
9271 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
9272 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
9273 | 50 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.04 | 2.00 | 2.00 | |||
9274 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
9277 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
Average | 0.8 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.8 | 0.02 | 0.02 | 1.25 | 1.25 | ||||
± SEM | 0.01 | 0.01 | 0.75 | 0.75 | ||||||||||||
Vehicle Control | No Stressor |
0 |
9278 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 |
9279 | 50 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 4 | 0.08 | 0.02 | 8.00 | 2.00 | |||
9281 | 50 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.02 | 6.00 | 2.00 | |||
9282 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.00 | 2.00 | 0.00 | |||
9283 | 50 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.00 | 2.00 | 0.00 | |||
9284 | 50 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.04 | 4.00 | 4.00 | |||
9285 | 50 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.02 | 6.00 | 2.00 | |||
9286 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.00 | 2.00 | 0.00 | |||
Average | 0.6 | 1.4 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.04 | 0.01 | 3.75 | 1.25 | ||||
± SEM | 0.01 | 0.01 | 0.96 | 0.53 | ||||||||||||
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation