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Study Information
Study Attribute Value
CEBS Accession Number: 002-02806-0007-0000-5
Chemical Name: Sodium (2-ethylhexyl)alcohol sulfate
CASRN: 126-92-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 795640_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/16/1993 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 13750 50 20 4 0 0 0 0 0 24 0.48 0.40 26.00 20.00
    13751 50 21 3 0 0 0 0 0 24 0.48 0.42 20.00 16.00
    13752 50 10 1 1 0 0 0 0 12 0.24 0.22 20.00 18.00
    13753 50 18 1 1 0 0 0 0 20 0.40 0.38 32.00 30.00
    13754 50 23 2 0 1 0 0 0 26 0.52 0.46 34.00 30.00
    13755 50 10 3 0 0 0 0 0 13 0.26 0.20 22.00 18.00
    13756 50 8 4 0 0 0 0 0 12 0.24 0.16 20.00 16.00
    13757 50 23 6 0 0 0 0 0 29 0.58 0.46 34.00 28.00
Average         16.6 3.0 0.3 0.1 0.0 0.0 0.0 20.0 0.40 0.34 26.00 22.00
± SEM                         0.05 0.04 2.27 2.20
 
Test Chemical Sodium (2-ethylhexyl)alcohol sulfate 
250         
 13710 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13711 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    13712 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13713 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13714 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    13715 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    13716 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    13717 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.9 0.0 0.0 0.0 0.0 0.0 1.4 0.03 0.01 2.75 1.00
± SEM                         0.01 0.01 0.53 0.53
 
Test Chemical Sodium (2-ethylhexyl)alcohol sulfate 
500         
 13720 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    13721 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13722 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13723 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13724 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13725 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13726 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    13727 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.4 0.3 0.0 0.0 0.0 0.0 0.0 0.6 0.01 0.01 1.25 0.75
± SEM                         0.01 0.00 0.65 0.37
 
Test Chemical Sodium (2-ethylhexyl)alcohol sulfate 
1000         
 13730 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13731 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    13732 50 3 8 0 0 0 0 0 11 0.22 0.06 14.00 4.00
    13733 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13734 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    13736 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13737 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13738 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         1.1 1.6 0.0 0.0 0.0 0.0 0.0 2.8 0.06 0.02 4.50 2.00
± SEM                         0.02 0.01 1.55 0.85
 
Vehicle Control No Stressor 
 0         
 13740 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13741 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13742 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13743 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    13744 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13745 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13746 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13748 50 1 3 0 0 0 0 0 4 0.08 0.02 6.00 2.00
Average         0.8 0.4 0.0 0.0 0.0 0.0 0.0 1.1 0.02 0.02 2.00 1.50
± SEM                         0.01 0.01 0.93 0.73
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation