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Study Information
Study Attribute Value
CEBS Accession Number: 002-02132-0010-0000-1
Chemical Name: Ethoxylated dodecyl alcohol
CASRN: 9002-92-0
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 844342_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
06/04/1991 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 11855 50 15 3 0 0 0 0 0 18 0.36 0.30 22.00 20.00
    11856 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11857 50 6 0 1 0 0 0 0 7 0.14 0.14 12.00 12.00
    11858 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    11860 50 4 1 0 0 0 0 0 5 0.10 0.08 8.00 6.00
    11862 50 8 3 0 0 0 0 0 11 0.22 0.16 16.00 10.00
    11863 50 18 2 0 0 0 0 0 20 0.40 0.36 28.00 24.00
    11864 50 2 2 0 0 0 0 0 4 0.08 0.04 4.00 2.00
Average         6.9 1.8 0.1 0.0 0.0 0.0 0.0 8.8 0.18 0.14 12.50 9.75
± SEM                         0.05 0.05 3.18 3.01
 
Test Chemical Ethoxylated dodecyl alcohol 
62.5       
 11825 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11826 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11827 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11828 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11829 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11830 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11831 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11832 50 1 1 0 0 0 0 0 2 0.04 0.02 2.00 2.00
Average         0.4 0.4 0.0 0.0 0.0 0.0 0.0 0.8 0.02 0.01 1.25 0.75
± SEM                         0.01 0.00 0.37 0.37
 
Test Chemical Ethoxylated dodecyl alcohol 
125         
 11835 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11836 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    11837 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11838 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    11839 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11840 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11841 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11842 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.8 0.3 0.0 0.0 0.0 0.0 0.0 1.0 0.02 0.02 2.00 1.50
± SEM                         0.01 0.01 0.93 0.82
 
Test Chemical Ethoxylated dodecyl alcohol 
250         
 11845 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    11846 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    11847 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11848 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11849 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    11850 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11851 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11852 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         1.0 0.5 0.0 0.0 0.0 0.0 0.0 1.5 0.03 0.02 3.00 2.00
± SEM                         0.01 0.01 0.65 0.65
 
Vehicle Control No Stressor 
 0         
 11865 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    11866 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11867 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    11868 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11869 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    11870 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11871 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11872 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.8 0.0 0.0 0.0 0.0 0.0 1.3 0.03 0.01 2.25 1.00
± SEM                         0.01 0.01 0.59 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation