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Study Information
Study Attribute Value
CEBS Accession Number: 002-02132-0010-0000-1
Chemical Name: Ethoxylated dodecyl alcohol
CASRN: 9002-92-0
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 844342_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
03/30/1993 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 13570 50 10 4 0 0 0 0 0 14 0.28 0.20 22.00 16.00
    13571 50 11 4 0 0 0 0 0 15 0.30 0.22 26.00 20.00
    13572 50 5 6 0 0 0 0 0 11 0.22 0.10 16.00 10.00
    13573 50 5 2 0 0 0 0 0 7 0.14 0.10 14.00 10.00
    13574 50 8 2 0 0 0 0 1 11 0.22 0.18 22.00 18.00
    13575 50 9 5 0 0 0 0 0 14 0.28 0.18 24.00 18.00
    13576 50 6 1 0 0 0 0 0 7 0.14 0.12 14.00 12.00
    13578 50 11 4 0 1 0 0 0 16 0.32 0.22 30.00 22.00
Average         8.1 3.5 0.0 0.1 0.0 0.0 0.1 11.9 0.24 0.17 21.00 15.75
± SEM                         0.02 0.02 2.07 1.62
 
Test Chemical Ethoxylated dodecyl alcohol 
75         
 13530 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13531 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    13532 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13533 50 0 0 1 0 0 0 0 1 0.02 0.02 2.00 2.00
    13534 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13535 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13536 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13537 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.1 0.1 0.0 0.0 0.0 0.0 0.8 0.02 0.01 1.50 1.25
± SEM                         0.01 0.01 0.98 0.75
 
Test Chemical Ethoxylated dodecyl alcohol 
112.5       
 13540 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13541 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    13542 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    13545 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13546 50 1 1 0 0 0 0 1 3 0.06 0.04 6.00 4.00
    13547 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    13548 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    13549 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.9 0.9 0.0 0.0 0.0 0.0 0.1 1.9 0.04 0.02 3.75 2.00
± SEM                         0.01 0.01 0.80 0.85
 
Test Chemical Ethoxylated dodecyl alcohol 
150         
 13550 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13551 50 0 3 0 0 0 0 0 3 0.06 0.00 4.00 0.00
    13552 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13553 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    13554 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13555 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13556 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    13557 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
Average         0.8 0.9 0.0 0.0 0.0 0.0 0.0 1.6 0.03 0.02 3.00 1.50
± SEM                         0.01 0.01 0.85 0.82
 
Vehicle Control No Stressor 
 0         
 13561 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13562 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13563 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    13564 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    13565 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13567 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13568 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13569 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.3 0.5 0.0 0.0 0.0 0.0 0.0 0.8 0.02 0.01 1.50 0.50
± SEM                         0.01 0.01 0.82 0.50
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation