| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02132-0009-0000-9 |
| Chemical Name: | Ethoxylated dodecyl alcohol |
| CASRN: | 9002-92-0 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 844342_SCE |
| Study Result: | Negative (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 01/22/1991 | Bone Marrow | 24 | Male | Mouse | B6C3F1 | subcutaneously implanted x 1, 24 hour | No Call |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
11585 | 25 | 2.32 | ± | 0.340 |
| 11586 | 25 | 2.89 | ± | 0.362 | |||
| 11587 | 25 | 3.92 | ± | 0.588 | |||
| 11588 | 25 | 2.53 | ± | 0.278 | |||
| Average | 2.92 | ± | 0.355 | ||||
| Test Chemical | Ethoxylated dodecyl alcohol |
50 |
11570 | 25 | 2.29 | ± | 0.263 |
| 11571 | 25 | 1.96 | ± | 0.303 | |||
| 11572 | 25 | 2.77 | ± | 0.340 | |||
| 11573 | 25 | 3.20 | ± | 0.373 | |||
| Average | 2.55 | ± | 0.271 | ||||
| Test Chemical | Ethoxylated dodecyl alcohol |
100 |
11575 | 25 | 2.45 | ± | 0.320 |
| 11576 | 25 | 4.70 | ± | 0.578 | |||
| 11577 | 25 | 2.80 | ± | 0.374 | |||
| 11578 | 25 | 4.58 | ± | 0.343 | |||
| Average | 3.63 | ± | 0.585 | ||||
| Test Chemical | Ethoxylated dodecyl alcohol |
200 |
11580 | 25 | 3.42 | ± | 0.398 |
| 11582 | 25 | 2.53 | ± | 0.318 | |||
| 8023 | 25 | 6.81 | ± | 0.738 | |||
| 8024 | 25 | 3.33 | ± | 0.282 | |||
| Average | 4.03 | ± | 0.950 | ||||
| Positive Control | Mitomycin-C |
0.5 |
11590 | 25 | 5.56 | ± | 0.542 |
| 11591 | 25 | 5.53 | ± | 0.477 | |||
| 11592 | 25 | 6.96 | ± | 0.492 | |||
| 11593 | 25 | 6.48 | ± | 0.444 | |||
| Average | 6.14 | ± | 0.353 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed