COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02171-0012-0000-6
Chemical Name: FD & C yellow no. 6
CASRN: 2783-94-0
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 848256_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
10/06/1987 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 6624 50 21 3 1 1 0 0 0 26 0.52 0.44 30.00 28.00
    6625 50 7 2 0 0 0 0 1 10 0.20 0.16 14.00 12.00
    6626 50 14 3 0 0 0 0 0 17 0.34 0.28 20.00 18.00
    6627 50 10 3 1 0 3 0 1 18 0.36 0.30 8.00 6.00
    6628 50 12 4 0 0 0 0 2 18 0.36 0.28 30.00 24.00
    6629 50 5 3 0 0 0 0 0 8 0.16 0.10 14.00 10.00
    6630 50 6 2 0 0 0 0 1 9 0.18 0.14 18.00 14.00
    6631 50 15 1 0 0 0 0 0 16 0.32 0.30 12.00 10.00
Average         11.3 2.6 0.3 0.1 0.4 0.0 0.6 15.3 0.31 0.25 18.25 15.25
± SEM                         0.04 0.04 2.86 2.67
 
Test Chemical FD & C yellow no. 6 
1225         
 6604 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    6605 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6606 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6607 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    6608 50 3 0 1 0 0 0 0 4 0.08 0.08 6.00 6.00
    6609 50 2 2 0 0 0 0 0 4 0.08 0.04 4.00 2.00
    6610 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6611 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         1.3 0.4 0.1 0.0 0.0 0.0 0.0 1.8 0.04 0.03 2.75 2.25
± SEM                         0.01 0.01 0.75 0.80
 
Test Chemical FD & C yellow no. 6 
2450         
 6594 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6595 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6596 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6597 50 0 0 1 0 0 0 0 1 0.02 0.02 2.00 2.00
    6598 50 1 0 1 0 0 0 0 2 0.04 0.04 4.00 4.00
    6599 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6600 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6601 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.6 0.0 0.3 0.0 0.0 0.0 0.0 0.9 0.02 0.02 1.75 1.75
± SEM                         0.00 0.00 0.45 0.45
 
Test Chemical FD & C yellow no. 6 
4900         
 6584 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6585 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    6586 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    6587 50 2 2 0 0 0 0 0 4 0.08 0.04 4.00 2.00
    6588 50 3 1 0 0 0 0 0 4 0.08 0.06 4.00 4.00
    6589 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6590 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6591 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
Average         1.0 0.9 0.0 0.0 0.0 0.0 0.0 1.9 0.04 0.02 2.75 1.50
± SEM                         0.01 0.01 0.92 0.63
 
Vehicle Control No Stressor 
 0         
 6614 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    6615 50 4 2 0 0 0 0 0 6 0.12 0.08 6.00 6.00
    6617 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6618 50 2 1 1 0 0 0 0 4 0.08 0.06 8.00 6.00
    6619 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    6620 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6621 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    6622 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         1.8 0.8 0.1 0.0 0.0 0.0 0.0 2.6 0.05 0.04 4.50 3.50
± SEM                         0.01 0.01 0.91 0.82
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation