Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02171-0012-0000-6 |
Chemical Name: | FD & C yellow no. 6 |
CASRN: | 2783-94-0 |
NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
NTP Study ID: | 848256_CA |
Study Result: | Negative |
Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.
Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Result |
---|---|---|---|---|---|---|---|
09/24/1991 | Bone Marrow | 36 | Male | Mouse | B6C3F1 | Intraperitoneal Injection x 1/study, 36 hour | Negative |
Dose (mg/kg) |
Animal Number |
No. Cells |
Chromatid | Isochromatid | Exchanges | Aberrations | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Breaks | Gaps | Breaks | Gaps | 'Tid | 'Some | Other | Total | Per Cell | % Cells w/ Abs | |||||||
(+ Gaps) | (- Gaps) | (+ Gaps) | (- Gaps) | |||||||||||||
Positive Control | Mitomycin-C |
1 |
12325 | 50 | 7 | 5 | 0 | 0 | 0 | 0 | 0 | 12 | 0.24 | 0.14 | 20.00 | 10.00 |
12326 | 50 | 16 | 1 | 1 | 0 | 0 | 0 | 1 | 19 | 0.38 | 0.36 | 28.00 | 26.00 | |||
12327 | 50 | 13 | 4 | 0 | 0 | 0 | 0 | 0 | 17 | 0.34 | 0.26 | 24.00 | 18.00 | |||
12328 | 50 | 13 | 2 | 0 | 0 | 0 | 0 | 1 | 16 | 0.32 | 0.28 | 28.00 | 26.00 | |||
12330 | 50 | 12 | 5 | 0 | 0 | 0 | 0 | 1 | 18 | 0.36 | 0.26 | 26.00 | 20.00 | |||
12331 | 50 | 14 | 5 | 0 | 0 | 0 | 0 | 0 | 19 | 0.38 | 0.28 | 30.00 | 22.00 | |||
12332 | 50 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 10 | 0.20 | 0.20 | 16.00 | 16.00 | |||
Average | 12.1 | 3.1 | 0.1 | 0.0 | 0.0 | 0.0 | 0.4 | 15.9 | 0.32 | 0.25 | 24.57 | 19.71 | ||||
± SEM | 0.03 | 0.03 | 1.89 | 2.16 | ||||||||||||
Test Chemical | FD & C yellow no. 6 |
1225 |
12255 | 50 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.06 | 6.00 | 6.00 |
12256 | 50 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 4 | 0.08 | 0.06 | 6.00 | 4.00 | |||
12257 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.00 | 2.00 | 0.00 | |||
12258 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
12259 | 50 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.00 | 4.00 | 0.00 | |||
12262 | 50 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.04 | 6.00 | 4.00 | |||
12263 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
12264 | 50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.02 | 4.00 | 2.00 | |||
Average | 1.1 | 0.8 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.9 | 0.04 | 0.02 | 3.50 | 2.00 | ||||
± SEM | 0.01 | 0.01 | 0.91 | 0.85 | ||||||||||||
Test Chemical | FD & C yellow no. 6 |
2450 |
12265 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.00 | 2.00 | 0.00 |
12266 | 50 | 5 | 3 | 0 | 0 | 0 | 0 | 0 | 8 | 0.16 | 0.10 | 14.00 | 10.00 | |||
12267 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
12268 | 50 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.00 | 4.00 | 0.00 | |||
12269 | 50 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.04 | 4.00 | 4.00 | |||
12270 | 50 | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 5 | 0.10 | 0.06 | 10.00 | 6.00 | |||
12271 | 50 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.04 | 4.00 | 4.00 | |||
12272 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
Average | 1.5 | 1.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.5 | 0.05 | 0.03 | 4.75 | 3.00 | ||||
± SEM | 0.02 | 0.01 | 1.73 | 1.31 | ||||||||||||
Test Chemical | FD & C yellow no. 6 |
4900 |
12275 | 50 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 4 | 0.08 | 0.06 | 8.00 | 6.00 |
12276 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
12277 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
12279 | 50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.02 | 4.00 | 2.00 | |||
12280 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.00 | 2.00 | 0.00 | |||
12281 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.00 | 2.00 | 0.00 | |||
12282 | 50 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 4 | 0.08 | 0.04 | 8.00 | 4.00 | |||
12283 | 50 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.02 | 6.00 | 2.00 | |||
Average | 0.9 | 0.9 | 0.1 | 0.1 | 0.0 | 0.0 | 0.0 | 2.0 | 0.04 | 0.02 | 4.00 | 2.00 | ||||
± SEM | 0.01 | 0.01 | 1.07 | 0.76 | ||||||||||||
Vehicle Control | No Stressor |
0 |
12315 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 |
12316 | 50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.02 | 4.00 | 2.00 | |||
12317 | 50 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.02 | 6.00 | 2.00 | |||
12318 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.00 | 2.00 | 0.00 | |||
12319 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
12320 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
12322 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.00 | 2.00 | 0.00 | |||
Average | 0.6 | 0.7 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.3 | 0.03 | 0.01 | 2.57 | 1.14 | ||||
± SEM | 0.01 | 0.00 | 0.72 | 0.40 | ||||||||||||
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation