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Study Information
Study Attribute Value
CEBS Accession Number: 002-02859-0011-0000-8
Chemical Name: Sulfisoxazole
CASRN: 127-69-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 855795_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/13/1986 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 4079 50 31 13 1 0 1 0 0 46 0.92 0.66 34.00 30.00
    4080 50 21 4 0 0 1 0 0 26 0.52 0.44 16.00 14.00
    4081 50 19 8 1 0 0 0 3 31 0.62 0.46 34.00 24.00
    4082 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    4083 50 14 9 1 0 0 0 0 24 0.48 0.30 32.00 28.00
    4084 50 36 14 3 0 0 0 0 53 1.06 0.78 50.00 38.00
    4085 50 23 2 0 0 0 0 0 25 0.50 0.46 26.00 26.00
    4086 50 18 5 2 0 0 0 0 25 0.50 0.40 32.00 30.00
Average         20.5 6.9 1.0 0.0 0.3 0.0 0.4 29.0 0.58 0.44 28.50 24.25
± SEM                         0.11 0.08 4.84 3.75
 
Test Chemical Sulfisoxazole 
550         
 4059 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4060 50 3 2 0 0 0 0 0 5 0.10 0.06 10.00 6.00
    4061 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4062 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4063 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    4064 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4065 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    4066 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         1.3 0.5 0.0 0.0 0.0 0.0 0.0 1.8 0.04 0.03 3.50 2.50
± SEM                         0.01 0.01 1.05 0.73
 
Test Chemical Sulfisoxazole 
1100         
 4049 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    4050 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4051 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4052 50 1 0 1 0 0 0 0 2 0.04 0.04 4.00 4.00
    4053 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4054 50 1 0 1 0 0 0 0 2 0.04 0.04 4.00 4.00
    4055 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4056 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.1 0.3 0.0 0.0 0.0 0.0 0.9 0.02 0.02 1.75 1.50
± SEM                         0.01 0.01 0.70 0.73
 
Test Chemical Sulfisoxazole 
2200         
 4039 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4040 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    4041 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    4042 50 4 1 2 0 0 0 0 7 0.14 0.12 12.00 10.00
    4043 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4044 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 2.00
    4045 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    4046 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
Average         2.0 0.8 0.3 0.0 0.0 0.0 0.0 3.0 0.06 0.05 5.50 4.00
± SEM                         0.01 0.01 1.18 1.00
 
Vehicle Control No Stressor 
 0         
 4069 50 1 0 1 0 0 0 0 2 0.04 0.04 4.00 4.00
    4070 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 4.00
    4071 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4072 50 1 1 1 0 0 0 0 3 0.06 0.04 6.00 4.00
    4073 50 3 0 0 0 0 0 0 3 0.06 0.06 4.00 4.00
    4074 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4075 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4076 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.3 0.3 0.3 0.0 0.0 0.0 0.0 1.8 0.04 0.03 3.00 2.50
± SEM                         0.01 0.01 0.85 0.63
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation