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Study Information
Study Attribute Value
CEBS Accession Number: 002-02859-0011-0000-8
Chemical Name: Sulfisoxazole
CASRN: 127-69-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 855795_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
03/21/1988 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 7610 50 17 11 1 0 2 0 0 31 0.62 0.40 40.00 26.00
    7611 50 12 4 0 0 0 0 0 16 0.32 0.24 14.00 12.00
    7612 50 28 3 0 1 0 0 1 33 0.66 0.58 42.00 36.00
    7613 50 24 10 3 0 0 0 0 37 0.74 0.54 44.00 38.00
    7614 50 35 6 1 0 0 0 0 42 0.84 0.72 40.00 38.00
    7615 50 11 5 2 1 1 0 0 20 0.40 0.28 30.00 24.00
    7616 50 23 15 3 0 0 0 0 41 0.82 0.52 44.00 34.00
    7617 50 13 3 1 0 0 0 0 17 0.34 0.28 24.00 18.00
Average         20.4 7.1 1.4 0.3 0.4 0.0 0.1 29.6 0.59 0.45 34.75 28.25
± SEM                         0.08 0.06 3.89 3.47
 
Test Chemical Sulfisoxazole 
550         
 7570 50 5 3 0 0 0 0 0 8 0.16 0.10 12.00 10.00
    7571 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    7572 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    7573 50 2 3 1 0 0 0 0 6 0.12 0.06 12.00 6.00
    7574 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    7575 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    7576 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    7577 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
Average         2.1 1.4 0.1 0.0 0.0 0.0 0.0 3.6 0.07 0.05 6.75 4.50
± SEM                         0.02 0.01 1.31 1.12
 
Test Chemical Sulfisoxazole 
1100         
 7580 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    7581 50 6 7 0 0 0 0 0 13 0.26 0.12 22.00 12.00
    7582 50 8 3 0 0 0 0 0 11 0.22 0.16 20.00 16.00
    7583 50 6 1 0 0 0 0 0 7 0.14 0.12 12.00 10.00
    7584 50 3 4 0 1 0 0 0 8 0.16 0.06 14.00 6.00
    7585 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    7586 50 5 3 0 0 0 0 0 8 0.16 0.10 16.00 10.00
    7587 50 3 2 1 0 0 0 0 6 0.12 0.08 10.00 6.00
Average         4.1 2.9 0.1 0.1 0.0 0.0 0.0 7.3 0.15 0.09 13.00 8.00
± SEM                         0.03 0.02 2.24 1.73
 
Test Chemical Sulfisoxazole 
2200         
 7590 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
    7591 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    7592 50 1 1 1 0 0 0 0 3 0.06 0.04 6.00 4.00
    7593 50 4 3 0 0 0 0 0 7 0.14 0.08 12.00 8.00
    7594 50 4 1 0 0 0 0 0 5 0.10 0.08 10.00 8.00
    7595 50 0 3 1 0 0 0 0 4 0.08 0.02 6.00 2.00
    7596 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    7597 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
Average         2.6 1.4 0.3 0.0 0.0 0.0 0.0 4.3 0.09 0.06 8.00 5.75
± SEM                         0.01 0.01 0.76 0.80
 
Vehicle Control No Stressor 
 0         
 7600 50 2 4 0 0 0 0 0 6 0.12 0.04 10.00 4.00
    7601 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    7602 50 5 3 0 0 0 0 0 8 0.16 0.10 16.00 10.00
    7603 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7604 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7605 50 4 5 0 0 0 0 0 9 0.18 0.08 14.00 8.00
    7606 50 2 2 1 0 0 0 0 5 0.10 0.06 10.00 6.00
    7607 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
Average         2.0 2.1 0.1 0.0 0.0 0.0 0.0 4.3 0.09 0.04 7.75 4.25
± SEM                         0.02 0.01 2.12 1.28
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation