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Study Information
Study Attribute Value
CEBS Accession Number: 002-02859-0011-0000-8
Chemical Name: Sulfisoxazole
CASRN: 127-69-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 855795_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
02/20/1990 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
50         
 10930 50 15 25 1 1 0 0 4 46 0.92 0.40 28.00 12.00
    10931 50 49 13 0 0 0 0 0 62 1.24 0.98 42.00 28.00
    10932 50 9 14 0 0 0 0 0 23 0.46 0.18 26.00 12.00
    10933 50 13 6 0 0 0 0 0 19 0.38 0.26 14.00 8.00
    10934 50 57 9 0 0 0 0 0 66 1.32 1.14 26.00 18.00
    10935 50 33 14 0 0 0 0 0 47 0.94 0.66 28.00 14.00
    10936 50 106 19 0 2 0 0 0 127 2.54 2.12 44.00 34.00
    10937 50 64 28 0 0 0 0 0 92 1.84 1.28 48.00 38.00
Average         43.3 16.0 0.1 0.4 0.0 0.0 0.5 60.3 1.21 0.88 32.00 20.50
± SEM                         0.25 0.23 4.07 4.00
 
Test Chemical Sulfisoxazole 
550         
 10890 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10891 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10893 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10894 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10895 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10896 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10897 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    10898 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.4 0.0 0.0 0.0 0.0 0.0 0.9 0.02 0.01 1.75 1.00
± SEM                         0.01 0.01 0.59 0.53
 
Test Chemical Sulfisoxazole 
1100         
 10900 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10901 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10903 50 0 3 1 0 0 0 0 4 0.08 0.02 8.00 2.00
    10904 50 7 4 0 0 0 0 0 11 0.22 0.14 18.00 12.00
    10905 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10906 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10907 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10908 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         1.1 1.3 0.1 0.0 0.0 0.0 0.0 2.5 0.05 0.03 4.50 2.25
± SEM                         0.03 0.02 2.13 1.44
 
Test Chemical Sulfisoxazole 
2200         
 10910 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10911 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10912 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10913 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    10914 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    10915 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10916 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    10917 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.9 0.4 0.0 0.0 0.0 0.0 0.0 1.3 0.03 0.02 2.50 1.75
± SEM                         0.01 0.01 0.73 0.59
 
Vehicle Control No Stressor 
 0         
 10920 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10921 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10922 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    10923 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10925 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10926 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10927 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10928 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.4 0.8 0.0 0.0 0.0 0.0 0.0 1.1 0.02 0.01 2.25 0.75
± SEM                         0.01 0.00 0.59 0.37
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation