| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02912-0011-0000-8 |
| Chemical Name: | Titanium dioxide |
| CASRN: | 13463-67-7 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 860815_SCE |
| Study Result: | Negative (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 07/26/1989 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
12598 | 23 | 3.11 | ± | 0.409 |
| 12601 | 24 | 4.35 | ± | 0.461 | |||
| 12620 | 25 | 4.41 | ± | 0.475 | |||
| 12628 | 25 | 5.59 | ± | 0.511 | |||
| Average | 4.39 | ± | 0.507 | ||||
| Test Chemical | Titanium dioxide |
625 |
12625 | 25 | 4.17 | ± | 0.427 |
| 12629 | 25 | 4.33 | ± | 0.465 | |||
| 12631 | 24 | 5.57 | ± | 0.475 | |||
| 12632 | 23 | 4.05 | ± | 0.386 | |||
| Average | 4.53 | ± | 0.350 | ||||
| Test Chemical | Titanium dioxide |
1250 |
12619 | 25 | 4.96 | ± | 0.561 |
| 12621 | 25 | 4.24 | ± | 0.501 | |||
| 12623 | 25 | 4.82 | ± | 0.443 | |||
| 12624 | 25 | 4.33 | ± | 0.576 | |||
| Average | 4.59 | ± | 0.178 | ||||
| Test Chemical | Titanium dioxide |
2500 |
12617 | 25 | 4.52 | ± | 0.459 |
| 12618 | 25 | 4.06 | ± | 0.399 | |||
| 12626 | 25 | 3.37 | ± | 0.306 | |||
| 12630 | 24 | 3.54 | ± | 0.343 | |||
| Average | 3.87 | ± | 0.261 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
12594 | 25 | 8.68 | ± | 0.650 |
| 12604 | 25 | 4.65 | ± | 0.453 | |||
| 12608 | 25 | 7.89 | ± | 0.735 | |||
| 12612 | 25 | 6.69 | ± | 0.637 | |||
| Average | 6.99 | ± | 0.877 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed