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Study Information
Study Attribute Value
CEBS Accession Number: 002-01690-0020-0000-0
Chemical Name: Benzene
CASRN: 71-43-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 867104_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
11/25/1986 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 4766 50 9 3 0 0 0 0 0 12 0.24 0.18 18.00 16.00
    4767 50 20 5 0 0 0 0 0 25 0.50 0.40 32.00 24.00
    4768 50 13 7 0 0 0 0 0 20 0.40 0.26 30.00 22.00
    4769 50 11 1 0 0 0 0 0 12 0.24 0.22 20.00 18.00
    4770 50 16 5 0 1 1 0 0 23 0.46 0.34 28.00 18.00
    4771 50 10 6 0 0 0 0 0 16 0.32 0.20 24.00 16.00
    4772 50 9 6 0 0 0 0 0 15 0.30 0.18 20.00 14.00
    4773 50 8 6 0 0 0 0 0 14 0.28 0.16 20.00 12.00
Average         12.0 4.9 0.0 0.1 0.1 0.0 0.0 17.1 0.34 0.24 24.00 17.50
± SEM                         0.04 0.03 1.89 1.40
 
Test Chemical Benzene 
1000         
 4696 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4697 50 2 3 0 0 0 0 0 5 0.10 0.04 10.00 4.00
    4698 50 13 5 1 0 0 0 0 19 0.38 0.28 28.00 24.00
    4699 50 13 5 0 0 0 0 1 19 0.38 0.28 26.00 22.00
    4700 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    4701 50 1 1 1 0 0 0 0 3 0.06 0.04 4.00 2.00
    4702 50 5 1 0 0 0 0 1 7 0.14 0.12 12.00 10.00
    4703 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
Average         5.0 2.1 0.3 0.0 0.0 0.0 0.3 7.6 0.15 0.11 11.75 9.25
± SEM                         0.05 0.04 3.53 3.18
 
Test Chemical Benzene 
2000         
 4706 50 3 2 0 0 0 0 0 5 0.10 0.06 10.00 6.00
    4707 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 4.00
    4708 50 2 1 1 0 0 0 0 4 0.08 0.06 8.00 6.00
    4709 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4710 50 6 2 1 0 0 0 0 9 0.18 0.14 14.00 12.00
    4711 50 2 0 1 0 0 0 0 3 0.06 0.06 4.00 4.00
    4712 50 4 0 1 0 0 0 0 5 0.10 0.10 8.00 8.00
    4713 50 18 3 0 0 0 0 1 22 0.44 0.38 28.00 26.00
Average         4.8 1.1 0.5 0.0 0.0 0.0 0.1 6.5 0.13 0.11 9.75 8.25
± SEM                         0.05 0.04 2.99 2.81
 
Test Chemical Benzene 
4000         
 4716 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4717 50 5 4 0 0 0 0 0 9 0.18 0.10 14.00 8.00
    4718 50 4 1 0 0 0 0 0 5 0.10 0.08 10.00 8.00
    4719 50 6 2 0 0 0 0 0 8 0.16 0.12 14.00 10.00
    4720 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    4721 50 6 6 0 0 0 0 0 12 0.24 0.12 22.00 12.00
    4722 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    4723 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
Average         3.4 2.1 0.0 0.0 0.0 0.0 0.0 5.5 0.11 0.07 10.00 6.25
± SEM                         0.03 0.02 2.39 1.58
 
Vehicle Control No Stressor 
 0         
 4756 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4757 50 7 0 0 0 0 0 0 7 0.14 0.14 6.00 6.00
    4758 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    4759 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    4760 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    4761 50 2 2 0 1 0 0 0 5 0.10 0.04 8.00 4.00
    4762 50 0 1 0 0 1 0 0 2 0.04 0.02 4.00 2.00
    4763 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         1.8 1.0 0.0 0.1 0.1 0.0 0.0 3.0 0.06 0.04 4.75 2.75
± SEM                         0.01 0.02 0.65 0.65
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation