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Study Information
Study Attribute Value
CEBS Accession Number: 002-01690-0020-0000-0
Chemical Name: Benzene
CASRN: 71-43-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 867104_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
02/05/1990 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
50         
 10850 50 71 1 0 0 1 0 0 73 1.46 1.44 30.00 30.00
    10851 50 6 4 3 1 0 0 0 14 0.28 0.18 10.00 8.00
    10852 50 7 3 0 0 0 0 0 10 0.20 0.14 18.00 12.00
    10853 50 35 9 1 0 0 0 0 45 0.90 0.72 34.00 24.00
    10854 50 12 2 0 0 0 0 0 14 0.28 0.24 20.00 18.00
    10855 50 17 5 0 0 0 0 0 22 0.44 0.34 30.00 22.00
    10856 50 120 6 0 0 0 0 0 126 2.52 2.40 46.00 44.00
    10857 50 4 2 0 0 0 0 0 6 0.12 0.08 12.00 8.00
Average         34.0 4.0 0.5 0.1 0.1 0.0 0.0 38.8 0.78 0.69 25.00 20.75
± SEM                         0.30 0.29 4.31 4.32
 
Test Chemical Benzene 
850         
 10780 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    10781 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10782 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10783 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    10784 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10785 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10786 50 3 5 1 0 0 0 0 9 0.18 0.08 16.00 6.00
    10787 50 3 0 0 0 0 0 0 3 0.06 0.06 4.00 4.00
Average         1.4 0.8 0.1 0.0 0.0 0.0 0.0 2.3 0.05 0.03 4.00 2.50
± SEM                         0.02 0.01 1.89 0.82
 
Test Chemical Benzene 
1700         
 10790 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10791 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    10792 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    10793 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10794 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10795 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    10796 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    10797 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.4 0.4 0.0 0.0 0.0 0.0 0.0 1.8 0.04 0.03 3.50 2.75
± SEM                         0.01 0.01 1.05 0.92
 
Test Chemical Benzene 
3400         
 10800 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10801 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    10802 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10803 50 3 3 0 0 0 0 0 6 0.12 0.06 8.00 6.00
    10804 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    10805 50 5 2 0 0 0 0 0 7 0.14 0.10 10.00 8.00
    10806 50 8 1 0 0 0 0 0 9 0.18 0.16 18.00 16.00
    10807 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         2.8 0.8 0.0 0.0 0.0 0.0 0.0 3.5 0.07 0.06 6.00 5.25
± SEM                         0.02 0.02 2.14 1.85
 
Vehicle Control No Stressor 
 0         
 10840 50 0 2 1 0 0 0 0 3 0.06 0.02 6.00 2.00
    10841 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10842 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10843 50 4 1 0 0 0 0 0 5 0.10 0.08 6.00 6.00
    10844 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10845 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    10846 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10847 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.1 0.8 0.1 0.0 0.0 0.0 0.0 2.0 0.04 0.03 3.50 2.25
± SEM                         0.01 0.01 0.82 0.59
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation