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Study Information
Study Attribute Value
CEBS Accession Number: 002-01690-0020-0000-0
Chemical Name: Benzene
CASRN: 71-43-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 867104_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
12/17/1990 Bone Marrow 35 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 35 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
50         
 11490 50 52 7 1 0 0 0 0 60 1.20 1.06 36.00 26.00
    11491 50 89 5 0 1 0 0 1 96 1.92 1.80 44.00 34.00
    11493 50 58 4 1 0 0 0 0 63 1.26 1.18 24.00 20.00
    11494 50 120 11 0 0 0 0 0 131 2.62 2.40 52.00 48.00
    11495 50 70 16 1 0 0 0 0 87 1.74 1.42 56.00 42.00
    11496 50 36 7 0 0 0 0 0 43 0.86 0.72 32.00 26.00
    11497 50 109 11 0 0 0 0 1 121 2.42 2.20 56.00 44.00
Average         76.3 8.7 0.4 0.1 0.0 0.0 0.3 85.9 1.72 1.54 42.86 34.29
± SEM                         0.25 0.23 4.76 4.03
 
Test Chemical Benzene 
1700         
 11450 50 1 3 0 0 0 0 2 6 0.12 0.06 10.00 4.00
    11451 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11452 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    11453 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11454 50 2 3 0 0 0 0 0 5 0.10 0.04 8.00 4.00
    11455 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11456 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11457 50 3 7 0 0 0 0 0 10 0.20 0.06 18.00 4.00
Average         1.0 2.0 0.0 0.0 0.0 0.0 0.3 3.3 0.07 0.03 5.75 2.00
± SEM                         0.03 0.01 2.19 0.65
 
Test Chemical Benzene 
2550         
 11460 50 2 1 0 0 0 0 1 4 0.08 0.06 8.00 6.00
    11461 50 1 1 1 0 0 0 0 3 0.06 0.04 6.00 4.00
    11462 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    11463 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11465 50 0 0 0 0 0 0 0 0 0.00 0.00 2.00 2.00
    11466 50 3 0 0 0 0 0 0 3 0.06 0.06 4.00 4.00
    11467 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11468 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.1 0.4 0.1 0.0 0.0 0.0 0.1 1.8 0.04 0.03 3.50 2.75
± SEM                         0.01 0.01 0.98 0.75
 
Test Chemical Benzene 
3400         
 11470 50 11 11 0 0 0 0 1 23 0.46 0.24 24.00 18.00
    11471 50 4 1 0 0 0 0 0 5 0.10 0.08 10.00 8.00
    11472 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11473 50 7 2 0 0 0 0 0 9 0.18 0.14 14.00 12.00
    11474 50 3 7 0 0 0 0 0 10 0.20 0.06 20.00 6.00
    11475 50 6 1 1 0 0 0 0 8 0.16 0.14 16.00 14.00
    11476 50 4 3 0 0 0 0 0 7 0.14 0.08 14.00 8.00
    11477 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         4.4 3.3 0.1 0.0 0.0 0.0 0.1 7.9 0.16 0.09 12.50 8.25
± SEM                         0.05 0.03 2.92 2.25
 
Vehicle Control No Stressor 
 0         
 11480 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11481 50 4 0 5 0 0 0 0 9 0.18 0.18 4.00 4.00
    11482 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11485 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    11486 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    11487 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11488 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11489 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         1.1 0.9 0.6 0.0 0.0 0.0 0.0 2.6 0.05 0.04 3.50 1.75
± SEM                         0.02 0.02 0.63 0.59
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation