Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02044-0018-0000-1 |
Chemical Name: | Diglycidyl resorcinol ether (DGRE) |
CASRN: | 101-90-6 |
NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
NTP Study ID: | 873378_CA |
Study Result: | Positive (Nonstandard Protocol) |
Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.
Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Result |
---|---|---|---|---|---|---|---|
08/21/1986 | Bone Marrow | 17 | Male | Mouse | B6C3F1 | Intraperitoneal Injection x 1/study, 17 hour | Positive (Nonstandard Protocol) |
Dose (mg/kg) |
Animal Number |
No. Cells |
Chromatid | Isochromatid | Exchanges | Aberrations | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Breaks | Gaps | Breaks | Gaps | 'Tid | 'Some | Other | Total | Per Cell | % Cells w/ Abs | |||||||
(+ Gaps) | (- Gaps) | (+ Gaps) | (- Gaps) | |||||||||||||
Positive Control | Dimethylbenzanthracene |
100 |
3873 | 50 | 8 | 9 | 0 | 0 | 0 | 0 | 0 | 17 | 0.34 | 0.16 | 16.00 | 12.00 |
3883 | 50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.02 | 4.00 | 2.00 | |||
3892 | 50 | 3 | 4 | 0 | 0 | 0 | 0 | 0 | 7 | 0.14 | 0.06 | 8.00 | 4.00 | |||
3895 | 50 | 6 | 2 | 0 | 0 | 0 | 0 | 0 | 8 | 0.16 | 0.12 | 14.00 | 12.00 | |||
3910 | 50 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 4 | 0.08 | 0.04 | 8.00 | 4.00 | |||
3921 | 50 | 5 | 4 | 0 | 0 | 0 | 0 | 0 | 9 | 0.18 | 0.10 | 12.00 | 6.00 | |||
3933 | 50 | 3 | 3 | 0 | 0 | 0 | 0 | 1 | 7 | 0.14 | 0.08 | 12.00 | 8.00 | |||
3937 | 50 | 5 | 4 | 1 | 0 | 0 | 0 | 2 | 12 | 0.24 | 0.16 | 18.00 | 14.00 | |||
Average | 4.1 | 3.6 | 0.1 | 0.0 | 0.0 | 0.0 | 0.4 | 8.3 | 0.17 | 0.09 | 11.50 | 7.75 | ||||
± SEM | 0.03 | 0.02 | 1.64 | 1.58 | ||||||||||||
Test Chemical | Diglycidyl resorcinol ether (DGRE) |
150 |
3906 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 |
3909 | 50 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.02 | 4.00 | 2.00 | |||
3914 | 50 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.06 | 6.00 | 6.00 | |||
3915 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.00 | 2.00 | 0.00 | |||
3924 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 2.00 | 2.00 | |||
3928 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
3932 | 50 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 4 | 0.08 | 0.02 | 6.00 | 2.00 | |||
3935 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
Average | 0.6 | 0.8 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.4 | 0.03 | 0.01 | 2.50 | 1.50 | ||||
± SEM | 0.01 | 0.01 | 0.91 | 0.73 | ||||||||||||
Test Chemical | Diglycidyl resorcinol ether (DGRE) |
300 |
3902 | 50 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.04 | 4.00 | 4.00 |
3913 | 50 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.00 | 2.00 | 0.00 | |||
3916 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
3918 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
3930 | 50 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.00 | 4.00 | 0.00 | |||
3936 | 50 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 4 | 0.08 | 0.04 | 8.00 | 4.00 | |||
3938 | 50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.02 | 4.00 | 2.00 | |||
3939 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
Average | 1.0 | 0.9 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.9 | 0.04 | 0.02 | 3.50 | 2.00 | ||||
± SEM | 0.01 | 0.01 | 0.73 | 0.53 | ||||||||||||
Test Chemical | Diglycidyl resorcinol ether (DGRE) |
600 |
3904 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 |
3911 | 50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.02 | 4.00 | 4.00 | |||
3912 | 50 | 6 | 1 | 2 | 0 | 0 | 0 | 0 | 9 | 0.18 | 0.16 | 14.00 | 6.00 | |||
3917 | 50 | 16 | 2 | 1 | 0 | 0 | 0 | 0 | 19 | 0.38 | 0.34 | 26.00 | 20.00 | |||
3920 | 50 | 5 | 1 | 1 | 0 | 0 | 0 | 0 | 7 | 0.14 | 0.12 | 12.00 | 10.00 | |||
3922 | 50 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.04 | 4.00 | 4.00 | |||
3926 | 50 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 0.10 | 0.10 | 8.00 | 8.00 | |||
3934 | 50 | 10 | 2 | 2 | 0 | 0 | 0 | 0 | 14 | 0.28 | 0.24 | 24.00 | 20.00 | |||
Average | 5.6 | 0.9 | 0.8 | 0.0 | 0.0 | 0.0 | 0.0 | 7.3 | 0.15 | 0.13 | 11.50 | 9.00 | ||||
± SEM | 0.05 | 0.04 | 3.35 | 2.62 | ||||||||||||
Vehicle Control | No Stressor |
0 |
3866 | 50 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 4 | 0.08 | 0.04 | 2.00 | 2.00 |
3868 | 50 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 0.06 | 0.06 | 4.00 | 4.00 | |||
3890 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
3901 | 50 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.02 | 6.00 | 2.00 | |||
3903 | 50 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 4 | 0.08 | 0.00 | 8.00 | 0.00 | |||
3919 | 50 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.00 | 4.00 | 0.00 | |||
3929 | 50 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.02 | 4.00 | 2.00 | |||
3940 | 50 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.00 | 4.00 | 0.00 | |||
Average | 0.9 | 1.8 | 0.0 | 0.0 | 0.0 | 0.0 | 0.1 | 2.8 | 0.06 | 0.02 | 4.25 | 1.50 | ||||
± SEM | 0.01 | 0.01 | 0.70 | 0.50 | ||||||||||||
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation