| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02044-0017-0000-0 |
| Chemical Name: | Diglycidyl resorcinol ether (DGRE) |
| CASRN: | 101-90-6 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 873378_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 10/02/1986 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
3946 | 25 | 4.76 | ± | 0.479 |
| 3953 | 24 | 4.38 | ± | 0.499 | |||
| 3966 | 25 | 5.46 | ± | 0.437 | |||
| 3967 | 24 | 5.64 | ± | 0.795 | |||
| Average | 5.07 | ± | 0.296 | ||||
| Test Chemical | Diglycidyl resorcinol ether (DGRE) |
125 |
3947 | 24 | 4.99 | ± | 0.532 |
| 3955 | 25 | 5.89 | ± | 0.493 | |||
| 3958 | 25 | 6.42 | ± | 0.723 | |||
| 3959 | 25 | 5.67 | ± | 0.643 | |||
| Average | 5.75 | ± | 0.295 | ||||
| Test Chemical | Diglycidyl resorcinol ether (DGRE) |
250 |
3945 | 25 | 5.08 | ± | 0.666 |
| 3950 | 25 | 7.06 | ± | 0.595 | |||
| 3956 | 25 | 5.88 | ± | 0.561 | |||
| 3962 | 25 | 5.19 | ± | 0.596 | |||
| Average | 5.80 | ± | 0.454 | ||||
| Test Chemical | Diglycidyl resorcinol ether (DGRE) |
500 |
3944 | 25 | 7.28 | ± | 0.739 |
| 3948 | 25 | 14.68 | ± | 1.211 | |||
| 3957 | 25 | 10.96 | ± | 1.017 | |||
| 3968 | 25 | 10.49 | ± | 1.004 | |||
| Average | 10.87 | ± | 1.515 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
3942 | 25 | 10.01 | ± | 0.658 |
| 3961 | 25 | 9.55 | ± | 0.729 | |||
| 3963 | 25 | 13.00 | ± | 1.012 | |||
| 3965 | 25 | 10.68 | ± | 1.069 | |||
| Average | 10.80 | ± | 0.764 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed