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Study Information
Study Attribute Value
CEBS Accession Number: 002-01432-0017-0000-0
Chemical Name: 3-Chloro-2-methylpropene
CASRN: 563-47-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 876278_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
07/31/1986 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 3923 50 13 12 0 2 0 0 0 27 0.54 0.26 36.00 20.00
    3924 50 6 2 0 0 0 0 0 8 0.16 0.12 16.00 12.00
    3925 50 4 3 0 0 0 0 0 7 0.14 0.08 12.00 8.00
    3926 50 10 3 2 0 1 0 1 17 0.34 0.28 24.00 22.00
    3927 50 6 1 0 0 0 0 0 7 0.14 0.12 10.00 10.00
    3928 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    3929 50 11 5 0 0 0 0 0 16 0.32 0.22 22.00 18.00
    3930 50 3 2 0 0 0 0 0 5 0.10 0.06 8.00 6.00
Average         6.9 3.6 0.3 0.3 0.1 0.0 0.1 11.3 0.23 0.15 16.75 12.50
± SEM                         0.06 0.03 3.56 2.38
 
Test Chemical 3-Chloro-2-methylpropene 
62.5       
 3903 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    3904 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    3905 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3906 50 4 2 0 0 0 0 0 6 0.12 0.08 8.00 6.00
    3907 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    3908 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3909 50 4 1 0 0 0 0 0 5 0.10 0.08 10.00 8.00
    3910 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.8 0.6 0.0 0.0 0.0 0.0 0.0 2.4 0.05 0.04 4.25 3.25
± SEM                         0.02 0.01 1.39 1.06
 
Test Chemical 3-Chloro-2-methylpropene 
125         
 3893 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3894 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3895 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    3896 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3897 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    3898 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3899 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3900 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 6.00
Average         1.0 0.3 0.0 0.0 0.0 0.0 0.0 1.3 0.03 0.02 2.25 2.00
± SEM                         0.01 0.01 0.80 0.76
 
Test Chemical 3-Chloro-2-methylpropene 
250         
 3883 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3884 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    3885 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    3886 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3887 50 4 1 0 0 0 0 0 5 0.10 0.08 10.00 8.00
    3888 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    3889 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    3890 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 4.00
Average         1.3 0.9 0.0 0.0 0.0 0.0 0.0 2.1 0.04 0.03 4.00 2.50
± SEM                         0.01 0.01 1.20 1.05
 
Vehicle Control No Stressor 
 0         
 3913 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3914 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    3915 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    3916 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3917 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3918 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3919 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    3920 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.4 0.6 0.0 0.0 0.0 0.0 0.0 1.0 0.02 0.01 2.00 0.75
± SEM                         0.01 0.01 0.93 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation