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Study Information
Study Attribute Value
CEBS Accession Number: 002-01432-0017-0000-0
Chemical Name: 3-Chloro-2-methylpropene
CASRN: 563-47-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 876278_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
03/21/1988 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 7610 50 17 11 1 0 2 0 0 31 0.62 0.40 40.00 26.00
    7611 50 12 4 0 0 0 0 0 16 0.32 0.24 14.00 12.00
    7612 50 28 3 0 1 0 0 1 33 0.66 0.58 42.00 36.00
    7613 50 24 10 3 0 0 0 0 37 0.74 0.54 44.00 38.00
    7614 50 35 6 1 0 0 0 0 42 0.84 0.72 40.00 38.00
    7615 50 11 5 2 1 1 0 0 20 0.40 0.28 30.00 24.00
    7616 50 23 15 3 0 0 0 0 41 0.82 0.52 44.00 34.00
    7617 50 13 3 1 0 0 0 0 17 0.34 0.28 24.00 18.00
Average         20.4 7.1 1.4 0.3 0.4 0.0 0.1 29.6 0.59 0.45 34.75 28.25
± SEM                         0.08 0.06 3.89 3.47
 
Test Chemical 3-Chloro-2-methylpropene 
62.5       
 7540 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    7541 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    7542 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    7543 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    7544 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    7545 50 5 0 2 0 0 0 0 7 0.14 0.14 12.00 12.00
    7546 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    7547 50 3 2 2 0 0 0 0 7 0.14 0.10 12.00 10.00
Average         2.3 0.6 0.5 0.0 0.0 0.0 0.0 3.4 0.07 0.06 6.25 5.25
± SEM                         0.02 0.02 1.33 1.41
 
Test Chemical 3-Chloro-2-methylpropene 
125         
 7550 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    7551 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    7552 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    7553 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 4.00
    7554 50 5 1 0 0 0 0 0 6 0.12 0.10 12.00 10.00
    7555 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 2.00
    7556 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    7557 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
Average         2.1 1.3 0.0 0.0 0.0 0.0 0.0 3.4 0.07 0.04 6.25 3.75
± SEM                         0.01 0.01 1.16 1.10
 
Test Chemical 3-Chloro-2-methylpropene 
250         
 7560 50 7 1 1 0 0 0 0 9 0.18 0.16 12.00 12.00
    7561 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    7562 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    7563 50 4 1 0 1 0 0 0 6 0.12 0.08 12.00 8.00
    7564 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    7565 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    7566 50 4 0 1 0 0 0 0 5 0.10 0.10 10.00 10.00
    7567 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         2.5 0.8 0.3 0.1 0.0 0.0 0.0 3.6 0.07 0.06 6.50 5.00
± SEM                         0.02 0.02 1.59 1.60
 
Vehicle Control No Stressor 
 0         
 7600 50 2 4 0 0 0 0 0 6 0.12 0.04 10.00 4.00
    7601 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    7602 50 5 3 0 0 0 0 0 8 0.16 0.10 16.00 10.00
    7603 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7604 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7605 50 4 5 0 0 0 0 0 9 0.18 0.08 14.00 8.00
    7606 50 2 2 1 0 0 0 0 5 0.10 0.06 10.00 6.00
    7607 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
Average         2.0 2.1 0.1 0.0 0.0 0.0 0.0 4.3 0.09 0.04 7.75 4.25
± SEM                         0.02 0.01 2.12 1.28
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation