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Study Information
Study Attribute Value
CEBS Accession Number: 002-01432-0017-0000-0
Chemical Name: 3-Chloro-2-methylpropene
CASRN: 563-47-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 876278_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
12/02/1991 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
50         
 12530 50 2 2 0 1 0 0 0 5 0.10 0.04 8.00 4.00
    12531 50 6 1 0 0 0 0 0 7 0.14 0.12 10.00 10.00
    12532 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    12533 50 7 2 0 0 0 0 0 9 0.18 0.14 18.00 14.00
    12534 50 8 3 0 0 0 0 0 11 0.22 0.16 20.00 16.00
    12535 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12536 50 4 0 0 0 0 0 0 4 0.08 0.08 6.00 6.00
Average         4.1 1.6 0.0 0.1 0.0 0.0 0.0 5.9 0.12 0.08 10.29 7.71
± SEM                         0.02 0.02 2.37 2.16
 
Test Chemical 3-Chloro-2-methylpropene 
62.5       
 12460 50 2 0 0 0 0 0 0 2 0.04 0.04 2.00 2.00
    12461 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12462 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 4.00
    12463 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    12464 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12465 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12466 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    12467 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 4.00
Average         1.3 0.6 0.0 0.0 0.0 0.0 0.0 1.9 0.04 0.03 3.00 2.25
± SEM                         0.01 0.01 0.65 0.59
 
Test Chemical 3-Chloro-2-methylpropene 
125         
 12470 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12471 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12472 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12473 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12474 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12475 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12476 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12477 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.01 0.01 0.75 0.50
± SEM                         0.00 0.00 0.37 0.33
 
Test Chemical 3-Chloro-2-methylpropene 
250         
 12480 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12481 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12482 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    12483 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12484 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12485 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12486 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12488 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.3 0.0 0.0 0.0 0.0 0.0 0.8 0.02 0.01 1.50 1.00
± SEM                         0.01 0.01 0.50 0.53
 
Vehicle Control No Stressor 
 0         
 12520 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12521 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12522 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    12523 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12524 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12527 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12528 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12529 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.6 0.01 0.01 1.25 1.00
± SEM                         0.01 0.01 0.53 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation