| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01432-0016-0000-9 |
| Chemical Name: | 3-Chloro-2-methylpropene |
| CASRN: | 563-47-3 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 876278_SCE |
| Study Result: | Negative (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 07/29/1986 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
3843 | 25 | 3.89 | ± | 0.353 |
| 3844 | 25 | 5.67 | ± | 0.643 | |||
| 3845 | 25 | 5.27 | ± | 0.548 | |||
| 3846 | 25 | 3.80 | ± | 0.454 | |||
| Average | 4.66 | ± | 0.478 | ||||
| Test Chemical | 3-Chloro-2-methylpropene |
62.5 |
3838 | 25 | 5.60 | ± | 0.539 |
| 3839 | 25 | 4.34 | ± | 0.405 | |||
| 3840 | 25 | 3.78 | ± | 0.425 | |||
| 3841 | 25 | 4.22 | ± | 0.371 | |||
| Average | 4.49 | ± | 0.391 | ||||
| Test Chemical | 3-Chloro-2-methylpropene |
125 |
3833 | 25 | 5.07 | ± | 0.520 |
| 3834 | 25 | 5.59 | ± | 0.571 | |||
| 3835 | 25 | 4.88 | ± | 0.539 | |||
| 3836 | 25 | 4.59 | ± | 0.447 | |||
| Average | 5.04 | ± | 0.212 | ||||
| Test Chemical | 3-Chloro-2-methylpropene |
250 |
3828 | 25 | 5.35 | ± | 0.691 |
| 3829 | 25 | 5.95 | ± | 0.763 | |||
| 3830 | 25 | 4.76 | ± | 0.477 | |||
| 3831 | 25 | 3.82 | ± | 0.365 | |||
| Average | 4.97 | ± | 0.454 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
3848 | 25 | 9.87 | ± | 0.826 |
| 3849 | 25 | 8.83 | ± | 0.708 | |||
| 3850 | 25 | 8.67 | ± | 0.900 | |||
| 3851 | 25 | 7.57 | ± | 0.850 | |||
| Average | 8.74 | ± | 0.470 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed