| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01432-0016-0000-9 |
| Chemical Name: | 3-Chloro-2-methylpropene |
| CASRN: | 563-47-3 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 876278_SCE |
| Study Result: | Negative (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 02/22/1988 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Not a Valid Test |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
7455 | 25 | 11.91 | ± | 1.340 |
| 7456 | 25 | 4.07 | ± | 0.363 | |||
| 7457 | 25 | 4.85 | ± | 0.669 | |||
| 7458 | 25 | 4.00 | ± | 0.465 | |||
| Average | 6.21 | ± | 1.911 | ||||
| Test Chemical | 3-Chloro-2-methylpropene |
62.5 |
7425 | 25 | 2.58 | ± | 0.412 |
| 7426 | 25 | 8.90 | ± | 0.996 | |||
| 7427 | 25 | 2.97 | ± | 0.367 | |||
| 7428 | 25 | 3.42 | ± | 0.369 | |||
| Average | 4.47 | ± | 1.486 | ||||
| Test Chemical | 3-Chloro-2-methylpropene |
125 |
7430 | 25 | 3.17 | ± | 0.469 |
| 7431 | 25 | 3.58 | ± | 0.461 | |||
| 7432 | 25 | 2.94 | ± | 0.393 | |||
| 7433 | 25 | 3.99 | ± | 0.547 | |||
| Average | 3.42 | ± | 0.231 | ||||
| Test Chemical | 3-Chloro-2-methylpropene |
250 |
7435 | 25 | 2.92 | ± | 0.372 |
| 7436 | 25 | 2.69 | ± | 0.435 | |||
| 7438 | 25 | 4.77 | ± | 0.528 | |||
| 7439 | 25 | 4.23 | ± | 0.492 | |||
| Average | 3.65 | ± | 0.504 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
7460 | 25 | 4.33 | ± | 0.429 |
| 7461 | 25 | 8.80 | ± | 0.676 | |||
| 7462 | 25 | 7.74 | ± | 0.929 | |||
| 7463 | 25 | 11.01 | ± | 0.738 | |||
| Average | 7.97 | ± | 1.391 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed