COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-03018-0012-0000-7
Chemical Name: Ziram
CASRN: 137-30-4
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 880520_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/07/1989 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
50         
 10339 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    10340 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    10341 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    10342 50 3 2 0 0 0 0 0 5 0.10 0.06 8.00 4.00
    10343 50 6 4 0 0 0 0 0 10 0.20 0.12 14.00 12.00
    10344 50 4 5 0 0 0 0 0 9 0.18 0.08 12.00 8.00
    10345 50 5 4 0 0 0 0 0 9 0.18 0.10 16.00 10.00
    10346 50 1 5 0 0 0 0 0 6 0.12 0.02 8.00 2.00
Average         2.9 3.3 0.0 0.0 0.0 0.0 0.0 6.1 0.12 0.06 9.75 5.50
± SEM                         0.02 0.01 1.33 1.40
 
Test Chemical Ziram 
5         
 10269 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10270 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10271 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10272 50 1 1 0 0 0 0 0 2 0.04 0.02 2.00 2.00
    10273 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10274 50 0 0 1 0 0 0 0 1 0.02 0.02 2.00 2.00
    10275 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10276 50 0 0 1 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.4 0.1 0.3 0.0 0.0 0.0 0.0 0.8 0.02 0.01 1.25 1.25
± SEM                         0.01 0.00 0.37 0.37
 
Test Chemical Ziram 
10         
 10279 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10280 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10281 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10282 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10283 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10284 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10285 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 4.00
    10286 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         0.6 0.6 0.0 0.0 0.0 0.0 0.0 1.3 0.03 0.01 2.25 1.00
± SEM                         0.01 0.01 0.80 0.53
 
Test Chemical Ziram 
20         
 10289 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10290 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10291 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    10292 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10293 50 2 3 0 0 0 0 0 5 0.10 0.04 8.00 4.00
    10294 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 4.00
    10295 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10296 50 4 1 0 0 0 0 0 5 0.10 0.08 8.00 8.00
Average         1.4 1.3 0.0 0.0 0.0 0.0 0.0 2.6 0.05 0.03 4.50 2.50
± SEM                         0.02 0.01 1.24 0.98
 
Vehicle Control No Stressor 
 0         
 10329 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10330 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10331 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10332 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10334 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10335 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10336 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10337 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.01 0.01 1.25 1.25
± SEM                         0.00 0.00 0.37 0.37
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation