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Study Information
Study Attribute Value
CEBS Accession Number: 002-03018-0012-0000-7
Chemical Name: Ziram
CASRN: 137-30-4
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 880520_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
01/05/1993 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
25         
 13354 50 79 5 0 0 0 0 0 84 1.68 1.58 34.00 26.00
    13355 50 64 3 1 0 0 0 0 68 1.36 1.30 22.00 18.00
    13356 50 77 11 1 0 0 0 0 89 1.78 1.56 42.00 30.00
    13357 50 108 5 0 0 0 0 0 113 2.26 2.16 34.00 26.00
    13358 50 120 6 1 0 0 0 0 127 2.54 2.42 46.00 38.00
    13359 50 37 9 1 0 0 0 0 47 0.94 0.76 40.00 30.00
    13360 50 60 9 1 0 0 0 0 70 1.40 1.22 32.00 28.00
    13361 50 51 4 0 0 0 0 0 55 1.10 1.02 30.00 24.00
Average         74.5 6.5 0.6 0.0 0.0 0.0 0.0 81.6 1.63 1.50 35.00 27.50
± SEM                         0.20 0.20 2.67 2.03
 
Test Chemical Ziram 
2.5       
 13284 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13285 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13286 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13287 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13288 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13289 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    13290 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13291 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.3 0.3 0.0 0.0 0.0 0.0 0.0 0.5 0.01 0.01 1.00 0.50
± SEM                         0.01 0.00 0.53 0.33
 
Test Chemical Ziram 
5         
 13294 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13295 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13296 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13297 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13298 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13299 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13300 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13301 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.6 0.01 0.01 1.25 1.00
± SEM                         0.01 0.01 0.53 0.53
 
Test Chemical Ziram 
10         
 13304 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13305 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13306 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13308 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    13309 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13310 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13311 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13313 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.8 0.02 0.01 1.50 1.25
± SEM                         0.01 0.01 1.05 0.84
 
Vehicle Control No Stressor 
 0         
 13344 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    13345 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13346 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13347 50 0 0 1 0 0 0 0 1 0.02 0.02 2.00 2.00
    13348 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13349 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13350 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13351 50 2 0 0 0 0 0 0 2 0.04 0.04 2.00 2.00
Average         0.6 0.1 0.1 0.0 0.0 0.0 0.0 0.9 0.02 0.02 1.50 1.25
± SEM                         0.01 0.01 0.50 0.37
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation