| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-03018-0011-0000-6 |
| Chemical Name: | Ziram |
| CASRN: | 137-30-4 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 880520_SCE |
| Study Result: | Negative (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 01/14/1991 | Bone Marrow | 24 | Male | Mouse | B6C3F1 | subcutaneously implanted x 1, 24 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
11530 | 25 | 3.41 | ± | 0.412 |
| 11531 | 25 | 3.65 | ± | 0.492 | |||
| 11532 | 25 | 2.28 | ± | 0.291 | |||
| 11533 | 25 | 2.76 | ± | 0.343 | |||
| Average | 3.03 | ± | 0.311 | ||||
| Test Chemical | Ziram |
2.5 |
11500 | 25 | 3.45 | ± | 0.396 |
| 11501 | 25 | 3.24 | ± | 0.333 | |||
| 11502 | 25 | 3.23 | ± | 0.335 | |||
| 11503 | 25 | 2.85 | ± | 0.378 | |||
| Average | 3.19 | ± | 0.125 | ||||
| Test Chemical | Ziram |
5 |
11505 | 25 | 6.35 | ± | 0.689 |
| 11506 | 25 | 3.40 | ± | 0.346 | |||
| 11507 | 25 | 3.55 | ± | 0.341 | |||
| 11508 | 25 | 4.72 | ± | 0.492 | |||
| Average | 4.49 | ± | 0.682 | ||||
| Test Chemical | Ziram |
10 |
11510 | 25 | 3.20 | ± | 0.443 |
| 11511 | 25 | 3.68 | ± | 0.320 | |||
| 11512 | 25 | 4.46 | ± | 0.435 | |||
| 11513 | 25 | 2.80 | ± | 0.342 | |||
| Average | 3.54 | ± | 0.357 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
11535 | 25 | 6.57 | ± | 0.526 |
| 11536 | 25 | 8.13 | ± | 0.885 | |||
| 11537 | 25 | 4.56 | ± | 0.541 | |||
| 11538 | 25 | 6.63 | ± | 0.716 | |||
| Average | 6.48 | ± | 0.731 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed