| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-03018-0011-0000-6 |
| Chemical Name: | Ziram |
| CASRN: | 137-30-4 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 880520_SCE |
| Study Result: | Negative (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 05/02/1989 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Not a Valid Test |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
10042 | 25 | 9.80 | ± | 1.223 |
| 10043 | 25 | 7.69 | ± | 0.728 | |||
| 10044 | 25 | 6.16 | ± | 0.621 | |||
| 10045 | 25 | 5.36 | ± | 0.538 | |||
| Average | 7.25 | ± | 0.977 | ||||
| Test Chemical | Ziram |
2.5 |
10012 | 25 | 7.89 | ± | 0.812 |
| 10013 | 25 | 4.76 | ± | 0.572 | |||
| 10014 | 25 | 4.20 | ± | 0.400 | |||
| 10015 | 25 | 9.15 | ± | 0.913 | |||
| Average | 6.50 | ± | 1.198 | ||||
| Test Chemical | Ziram |
5 |
10017 | 25 | 5.52 | ± | 0.698 |
| 10018 | 25 | 5.10 | ± | 0.594 | |||
| 10019 | 25 | 6.40 | ± | 0.896 | |||
| 10020 | 25 | 4.88 | ± | 0.545 | |||
| Average | 5.47 | ± | 0.336 | ||||
| Test Chemical | Ziram |
10 |
10022 | 25 | 7.52 | ± | 0.920 |
| 10023 | 25 | 5.69 | ± | 0.531 | |||
| 10024 | 25 | 4.76 | ± | 0.590 | |||
| 10025 | 25 | 4.80 | ± | 0.412 | |||
| Average | 5.69 | ± | 0.646 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
10047 | 25 | 7.80 | ± | 0.768 |
| 10048 | 25 | 6.93 | ± | 0.516 | |||
| 10049 | 25 | 9.62 | ± | 0.943 | |||
| 10050 | 25 | 11.66 | ± | 0.765 | |||
| Average | 9.00 | ± | 1.049 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed