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Study Information
Study Attribute Value
CEBS Accession Number: 002-02492-0012-0000-2
Chemical Name: Monuron
CASRN: 150-68-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 881444_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
06/01/1989 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 12045 50 10 21 0 0 0 0 0 31 0.62 0.20 34.00 18.00
    12062 50 7 7 0 0 0 0 0 14 0.28 0.14 16.00 12.00
    12064 50 9 2 0 0 0 0 0 11 0.22 0.18 16.00 14.00
    12068 50 6 4 0 0 0 0 0 10 0.20 0.12 16.00 12.00
    12077 50 15 16 0 0 0 0 2 33 0.66 0.34 38.00 26.00
    12105 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12111 50 13 7 0 0 0 0 0 20 0.40 0.26 20.00 8.00
    12120 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
Average         7.6 7.5 0.0 0.0 0.0 0.0 0.3 15.4 0.31 0.16 18.50 11.50
± SEM                         0.08 0.04 4.37 2.97
 
Test Chemical Monuron 
125         
 12046 50 3 2 0 0 0 0 0 5 0.10 0.06 10.00 6.00
    12050 50 2 1 0 0 0 0 1 4 0.08 0.06 6.00 4.00
    12058 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12061 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12065 50 0 4 0 0 0 0 0 4 0.08 0.00 6.00 0.00
    12070 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    12071 50 4 3 0 0 0 0 0 7 0.14 0.08 10.00 6.00
    12072 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
Average         1.5 1.8 0.0 0.0 0.0 0.0 0.1 3.4 0.07 0.03 5.75 2.75
± SEM                         0.02 0.01 1.22 0.84
 
Test Chemical Monuron 
250         
 12043 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12047 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12049 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    12051 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12053 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12055 50 1 8 0 0 0 0 0 9 0.18 0.02 16.00 2.00
    12066 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12067 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
Average         0.6 2.0 0.0 0.0 0.0 0.0 0.0 2.6 0.05 0.01 5.00 1.25
± SEM                         0.02 0.00 1.65 0.37
 
Test Chemical Monuron 
500         
 12060 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12069 50 1 0 0 0 0 0 1 2 0.04 0.04 4.00 4.00
    12073 50 0 4 0 0 0 0 0 4 0.08 0.00 6.00 0.00
    12075 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12079 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12081 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12082 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12084 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.8 0.0 0.0 0.0 0.0 0.1 1.4 0.03 0.01 2.50 1.25
± SEM                         0.01 0.01 0.63 0.53
 
Vehicle Control No Stressor 
 0         
 12056 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    12063 50 1 6 0 0 0 0 0 7 0.14 0.02 10.00 2.00
    12074 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12080 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12083 50 3 2 0 0 0 0 1 6 0.12 0.08 8.00 6.00
    12095 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12103 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12109 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.6 1.4 0.0 0.0 0.0 0.0 0.1 2.1 0.04 0.02 3.25 1.25
± SEM                         0.02 0.01 1.36 0.75
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation