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Study Information
Study Attribute Value
CEBS Accession Number: 002-02492-0012-0000-2
Chemical Name: Monuron
CASRN: 150-68-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 881444_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/07/1989 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
25         
 12701 50 27 3 0 0 1 0 0 31 0.62 0.56 22.00 18.00
    12703 50 20 5 3 1 0 0 1 30 0.60 0.48 20.00 12.00
    12708 50 6 4 0 0 0 0 0 10 0.20 0.12 16.00 10.00
    12735 50 5 1 1 0 0 0 0 7 0.14 0.12 12.00 10.00
Average         14.5 3.3 1.0 0.3 0.3 0.0 0.3 19.5 0.39 0.32 17.50 12.50
± SEM                         0.13 0.12 2.22 1.89
 
Test Chemical Monuron 
125         
 12745 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12755 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    12756 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 2.00
    12760 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    12762 50 4 2 0 0 0 0 0 6 0.12 0.08 12.00 8.00
    12763 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12778 50 0 3 0 0 0 0 1 4 0.08 0.02 8.00 0.00
    12782 50 1 1 0 0 0 0 1 3 0.06 0.04 4.00 2.00
Average         1.1 1.6 0.0 0.0 0.0 0.0 0.3 3.0 0.06 0.03 5.75 2.00
± SEM                         0.01 0.01 1.28 0.93
 
Test Chemical Monuron 
250         
 12741 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12758 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12759 50 0 2 0 0 0 0 1 3 0.06 0.02 4.00 0.00
    12761 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12765 50 2 3 0 0 0 0 0 5 0.10 0.04 8.00 4.00
    12768 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12772 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12780 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.4 1.0 0.0 0.0 0.0 0.0 0.1 1.5 0.03 0.01 2.50 0.75
± SEM                         0.01 0.01 0.91 0.53
 
Test Chemical Monuron 
500         
 12742 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12747 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    12748 50 1 1 0 0 0 0 1 3 0.06 0.04 4.00 2.00
    12749 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 4.00
    12750 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12754 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12766 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12770 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.4 1.0 0.0 0.0 0.0 0.0 0.1 1.5 0.03 0.01 2.50 0.75
± SEM                         0.01 0.01 0.73 0.53
 
Vehicle Control No Stressor 
 0         
 12716 50 0 0 0 0 0 0 2 2 0.04 0.04 4.00 4.00
    12720 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    12725 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12743 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12744 50 1 1 0 0 0 0 0 2 0.04 0.02 2.00 2.00
Average         0.4 1.0 0.0 0.0 0.0 0.0 0.4 1.8 0.04 0.02 3.20 1.60
± SEM                         0.00 0.01 0.49 0.75
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation