| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02492-0011-0000-1 |
| Chemical Name: | Monuron |
| CASRN: | 150-68-5 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 881444_SCE |
| Study Result: | Negative (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 07/26/1989 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Not a Valid Test |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
12598 | 23 | 3.11 | ± | 0.409 |
| 12601 | 24 | 4.35 | ± | 0.461 | |||
| 12620 | 25 | 4.41 | ± | 0.475 | |||
| 12628 | 25 | 5.59 | ± | 0.511 | |||
| Average | 4.39 | ± | 0.507 | ||||
| Test Chemical | Monuron |
50 |
12591 | 24 | 5.17 | ± | 0.720 |
| 12600 | 24 | 4.09 | ± | 0.520 | |||
| 12603 | 25 | 3.68 | ± | 0.340 | |||
| 12613 | 25 | 4.00 | ± | 0.499 | |||
| Average | 4.23 | ± | 0.324 | ||||
| Test Chemical | Monuron |
100 |
12595 | 25 | 2.73 | ± | 0.367 |
| 12596 | 25 | 5.97 | ± | 0.624 | |||
| 12602 | 24 | 4.39 | ± | 0.529 | |||
| 12606 | 25 | 5.60 | ± | 0.577 | |||
| Average | 4.67 | ± | 0.730 | ||||
| Test Chemical | Monuron |
200 |
12593 | 25 | 4.45 | ± | 0.516 |
| 12607 | 25 | 5.96 | ± | 0.599 | |||
| 12610 | 25 | 5.42 | ± | 0.519 | |||
| 12611 | 24 | 5.84 | ± | 0.918 | |||
| Average | 5.41 | ± | 0.343 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
12594 | 25 | 8.68 | ± | 0.650 |
| 12604 | 25 | 4.65 | ± | 0.453 | |||
| 12608 | 25 | 7.89 | ± | 0.735 | |||
| 12612 | 25 | 6.69 | ± | 0.637 | |||
| Average | 6.99 | ± | 0.877 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed