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Study Information
Study Attribute Value
CEBS Accession Number: 002-02877-0012-0000-9
Chemical Name: Tetrachlorophthalic anhydride
CASRN: 117-08-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 927311_SCE
Study Result: Positive (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.


Detailed Sister Chromatid Exchange Data (Trial 1)
Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Trial Result
06/12/1984 Bone Marrow 23 Male Mouse B6C3F1 IP/IJ x 1,  23 hour Positive

Test Group Dose
(mg/kg)		 Animal
Number		 No.
Cells		 SCE / Cell
Mean ± SEM
Vehicle Control Dimethyl Sulfoxide 
 0         
 1596 25 3.89 ± 0.473
    1597 25 3.50 ± 0.511
    1598 25 4.06 ± 0.396
    1599 25 6.41 ± 1.051
Average   4.47 ± 0.658
 
Test Chemical Tetrachlorophthalic anhydride 
100         
 1576 25 5.55 ± 0.566
    1577 25 5.20 ± 0.420
    1578 25 5.87 ± 0.552
    1579 25 4.97 ± 0.528
Average   5.40 ± 0.197
 
Test Chemical Tetrachlorophthalic anhydride 
200         
 1581 25 6.49 ± 0.781
    1582 25 5.39 ± 0.510
    1583 25 5.12 ± 0.540
    1584 25 5.79 ± 0.600
Average   5.70 ± 0.298
 
Test Chemical Tetrachlorophthalic anhydride 
400         
 1586 25 5.14 ± 0.607
    1587 25 5.88 ± 0.606
    1588 25 5.68 ± 0.468
    1589 25 9.37 ± 0.883
Average   6.52 ± 0.963
 
Positive Control Dimethylbenzanthracene 
10         
 1541 25 14.47 ± 1.040
    1542 25 10.12 ± 0.754
    1543 25 13.22 ± 1.336
    1544 25 13.34 ± 1.011
Average   12.79 ± 0.932
 

Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed