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Study Information
Study Attribute Value
CEBS Accession Number: 002-03143-0012-0000-6
Chemical Name: o-Toluidine hydrochloride
CASRN: 636-21-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 938330_CA
Study Result: Not a Valid Test


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/21/1985 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Not a Valid Test

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 2382 50 2 0 0 1 0 0 0 3 0.06 0.04 6.00 4.00
    2383 50 5 0 0 0 0 0 0 5 0.10 0.10 10.00 10.00
    2384 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    2385 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2386 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    2387 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2388 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2389 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         1.4 0.3 0.0 0.1 0.0 0.0 0.0 1.8 0.04 0.03 3.50 2.75
± SEM                         0.01 0.01 1.24 1.19
 
Test Chemical o-Toluidine hydrochloride 
150         
 2342 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2343 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2344 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2345 50 0 0 0 0 0 0 1 1 0.02 0.02 2.00 2.00
    2346 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2347 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2348 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2349 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         0.3 0.5 0.0 0.0 0.0 0.0 0.1 0.9 0.02 0.01 1.75 0.75
± SEM                         0.00 0.00 0.45 0.37
 
Test Chemical o-Toluidine hydrochloride 
300         
 2352 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    2353 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2354 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2355 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2357 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2358 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2359 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         0.6 0.1 0.0 0.0 0.0 0.0 0.1 0.9 0.02 0.01 1.43 1.14
± SEM                         0.01 0.01 0.57 0.59
 
Test Chemical o-Toluidine hydrochloride 
600         
 2362 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2363 50 0 0 0 1 0 0 0 1 0.02 0.00 2.00 0.00
    2365 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2366 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2367 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2368 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2369 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.4 0.01 0.01 0.86 0.57
± SEM                         0.00 0.00 0.40 0.37
 
Vehicle Control No Stressor 
 0         
 2372 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2374 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2375 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2376 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2377 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2378 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2379 50 1 3 1 0 0 0 0 5 0.10 0.04 10.00 4.00
    2380 50 2 4 1 0 0 0 0 7 0.14 0.06 12.00 4.00
Average         0.6 1.1 0.3 0.0 0.0 0.0 0.0 2.0 0.04 0.02 3.75 1.50
± SEM                         0.02 0.01 1.62 0.63
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation