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Study Information
Study Attribute Value
CEBS Accession Number: 002-03143-0012-0000-6
Chemical Name: o-Toluidine hydrochloride
CASRN: 636-21-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 938330_CA
Study Result: Not a Valid Test


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
05/27/1987 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Not a Valid Test

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 5771 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    5772 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    5773 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    5774 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    5775 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    5777 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5778 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    5780 50 4 2 0 0 0 0 0 6 0.12 0.08 10.00 6.00
Average         1.8 1.1 0.0 0.0 0.0 0.0 0.0 2.9 0.06 0.04 5.50 3.25
± SEM                         0.01 0.01 1.12 0.92
 
Test Chemical o-Toluidine hydrochloride 
150         
 5731 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5732 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    5733 50 5 2 0 0 0 0 0 7 0.14 0.10 10.00 8.00
    5734 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5735 50 2 2 0 1 0 0 0 5 0.10 0.04 10.00 4.00
    5736 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    5737 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    5738 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
Average         1.4 1.0 0.0 0.1 0.0 0.0 0.0 2.5 0.05 0.03 4.25 2.50
± SEM                         0.02 0.01 1.44 0.91
 
Test Chemical o-Toluidine hydrochloride 
300         
 5741 50 5 2 3 0 1 0 0 11 0.22 0.18 16.00 16.00
    5742 50 4 1 0 0 0 0 0 5 0.10 0.08 8.00 6.00
    5743 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    5744 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    5745 50 3 0 0 0 0 0 0 3 0.06 0.06 4.00 4.00
    5746 50 4 7 0 0 0 0 0 11 0.22 0.08 14.00 6.00
    5747 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    5748 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         2.8 1.9 0.4 0.0 0.1 0.0 0.0 5.1 0.10 0.07 7.75 5.50
± SEM                         0.03 0.02 1.75 1.68
 
Test Chemical o-Toluidine hydrochloride 
600         
 5751 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
    5752 50 2 3 0 0 0 0 0 5 0.10 0.04 8.00 4.00
    5753 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    5756 50 2 1 0 1 0 0 0 4 0.08 0.04 8.00 4.00
    5757 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
    5758 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    5760 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         2.3 0.7 0.0 0.1 0.0 0.0 0.0 3.1 0.06 0.05 6.00 4.57
± SEM                         0.01 0.01 0.98 0.95
 
Vehicle Control No Stressor 
 0         
 5761 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    5762 50 7 0 0 0 0 0 0 7 0.14 0.14 12.00 12.00
    5763 50 0 0 0 0 0 0 1 1 0.02 0.02 2.00 2.00
    5764 50 2 0 0 1 0 0 0 3 0.06 0.04 4.00 2.00
    5765 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    5766 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5767 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    5768 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         1.6 0.6 0.0 0.1 0.0 0.0 0.1 2.5 0.05 0.04 4.50 3.00
± SEM                         0.02 0.02 1.30 1.36
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation