| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-03143-0011-0000-5 |
| Chemical Name: | o-Toluidine hydrochloride |
| CASRN: | 636-21-5 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 938330_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 06/26/1985 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Dimethyl Sulfoxide |
0 |
2273 | 25 | 3.29 | ± | 0.470 |
| 2274 | 25 | 3.93 | ± | 0.499 | |||
| 2276 | 25 | 3.25 | ± | 0.349 | |||
| 2277 | 25 | 2.94 | ± | 0.275 | |||
| Average | 3.35 | ± | 0.206 | ||||
| Test Chemical | o-Toluidine hydrochloride |
150 |
2233 | 25 | 4.16 | ± | 0.390 |
| 2234 | 25 | 4.91 | ± | 0.438 | |||
| 2235 | 25 | 3.88 | ± | 0.360 | |||
| 2236 | 25 | 5.07 | ± | 0.507 | |||
| Average | 4.51 | ± | 0.288 | ||||
| Test Chemical | o-Toluidine hydrochloride |
300 |
2238 | 25 | 6.59 | ± | 0.702 |
| 2239 | 25 | 4.09 | ± | 0.320 | |||
| 2241 | 25 | 7.14 | ± | 0.744 | |||
| 2242 | 25 | 6.69 | ± | 0.774 | |||
| Average | 6.13 | ± | 0.689 | ||||
| Test Chemical | o-Toluidine hydrochloride |
600 |
2243 | 25 | 7.52 | ± | 1.176 |
| 2244 | 25 | 6.05 | ± | 0.593 | |||
| 2245 | 25 | 6.35 | ± | 0.543 | |||
| 2247 | 25 | 5.97 | ± | 0.637 | |||
| Average | 6.47 | ± | 0.358 | ||||
| Positive Control | Mitomycin-C |
0.5 |
2263 | 25 | 8.59 | ± | 0.477 |
| 2264 | 25 | 7.23 | ± | 0.665 | |||
| 2265 | 25 | 11.19 | ± | 0.779 | |||
| 2266 | 25 | 9.08 | ± | 0.483 | |||
| Average | 9.03 | ± | 0.821 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed