| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-03143-0011-0000-5 |
| Chemical Name: | o-Toluidine hydrochloride |
| CASRN: | 636-21-5 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 938330_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 08/01/1988 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
8558 | 25 | 2.96 | ± | 0.313 |
| 8559 | 25 | 5.54 | ± | 0.640 | |||
| 8560 | 25 | 4.76 | ± | 0.661 | |||
| 8561 | 25 | 3.72 | ± | 0.402 | |||
| Average | 4.25 | ± | 0.568 | ||||
| Test Chemical | o-Toluidine hydrochloride |
450 |
8518 | 25 | 10.46 | ± | 0.816 |
| 8519 | 25 | 8.13 | ± | 0.843 | |||
| 8520 | 25 | 5.32 | ± | 0.489 | |||
| 8521 | 25 | 10.04 | ± | 1.456 | |||
| Average | 8.49 | ± | 1.172 | ||||
| Test Chemical | o-Toluidine hydrochloride |
600 |
8523 | 25 | 7.03 | ± | 0.962 |
| 8525 | 25 | 6.06 | ± | 0.790 | |||
| 8526 | 25 | 5.98 | ± | 0.338 | |||
| Average | 6.35 | ± | 0.338 | ||||
| Positive Control | Mitomycin-C |
1 |
8563 | 25 | 6.76 | ± | 0.698 |
| 8564 | 25 | 7.06 | ± | 0.579 | |||
| 8565 | 25 | 6.92 | ± | 0.624 | |||
| 8566 | 25 | 6.28 | ± | 0.430 | |||
| Average | 6.76 | ± | 0.169 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed