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Study Information
Study Attribute Value
CEBS Accession Number: 002-02393-0012-0000-2
Chemical Name: Melamine
CASRN: 108-78-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 951364_CA
Study Result: Positive (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
02/07/1989 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive (Nonstandard Protocol)

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
25         
 11065 50 31 1 0 0 0 0 0 32 0.64 0.62 10.00 8.00
    11068 50 4 1 0 0 0 0 0 5 0.10 0.08 10.00 8.00
    11076 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11078 50 10 24 0 0 0 0 0 34 0.68 0.20 26.00 12.00
    11083 50 0 5 0 0 0 0 0 5 0.10 0.00 6.00 0.00
    11095 50 2 4 0 0 0 0 0 6 0.12 0.04 8.00 2.00
    11102 50 14 3 0 0 0 0 0 17 0.34 0.28 12.00 8.00
    11104 50 3 4 0 0 0 0 0 7 0.14 0.06 10.00 6.00
Average         8.1 5.4 0.0 0.0 0.0 0.0 0.0 13.5 0.27 0.16 10.75 5.75
± SEM                         0.09 0.07 2.36 1.44
 
Test Chemical Melamine 
150         
 11058 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11061 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    11064 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11077 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11079 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11088 50 0 3 0 0 0 0 0 3 0.06 0.00 4.00 0.00
    11089 50 2 3 0 0 0 0 1 6 0.12 0.06 8.00 6.00
    11100 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.5 1.1 0.0 0.0 0.0 0.0 0.1 1.8 0.04 0.01 2.75 1.25
± SEM                         0.01 0.01 0.92 0.75
 
Test Chemical Melamine 
300         
 11057 50 1 4 0 1 0 0 0 6 0.12 0.02 10.00 2.00
    11072 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11074 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11081 50 3 3 0 0 0 0 0 6 0.12 0.06 8.00 6.00
    11085 50 4 17 0 0 0 0 0 21 0.42 0.08 20.00 8.00
    11090 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    11092 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11107 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         1.3 3.5 0.0 0.1 0.0 0.0 0.0 4.9 0.10 0.03 6.25 2.50
± SEM                         0.05 0.01 2.34 1.05
 
Test Chemical Melamine 
600         
 11066 50 1 7 0 0 0 0 0 8 0.16 0.02 16.00 2.00
    11067 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    11070 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11086 50 0 5 0 0 0 0 0 5 0.10 0.00 10.00 0.00
    11091 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11098 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11099 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11108 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.5 2.4 0.0 0.0 0.0 0.0 0.0 2.9 0.06 0.01 5.75 1.00
± SEM                         0.02 0.00 1.75 0.38
 
Vehicle Control No Stressor 
 0         
 11060 50 0 4 0 0 0 0 0 4 0.08 0.00 8.00 0.00
    11069 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11073 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11075 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    11082 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11084 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11094 50 0 1 0 0 0 0 1 2 0.04 0.02 2.00 0.00
    11096 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         0.4 1.1 0.0 0.0 0.0 0.0 0.1 1.6 0.03 0.01 3.00 0.75
± SEM                         0.01 0.00 0.85 0.37
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation