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Study Information
Study Attribute Value
CEBS Accession Number: 002-02563-0005-0000-3
Chemical Name: N-Nitrosomorpholine
CASRN: 59-89-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 958084_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
06/22/1983 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Test Chemical N-Nitrosomorpholine 
375         
 622 50 22 18 0 1 0 0 103 144 2.88 2.50 48.00 36.00
    624 50 5 7 0 0 0 0 100 112 2.24 2.10 20.00 12.00
    625 50 4 6 0 0 0 0 75 85 1.70 1.58 18.00 8.00
    626 50 7 5 1 0 0 0 88 101 2.02 1.92 18.00 12.00
    627 50 3 10 1 1 0 0 92 107 2.14 1.92 24.00 8.00
    629 50 16 26 1 4 0 0 103 150 3.00 2.40 54.00 26.00
    904 50 3 4 1 0 0 0 1 9 0.18 0.10 10.00 4.00
    930 50 7 6 0 0 0 0 0 13 0.26 0.14 18.00 8.00
Average         8.4 10.3 0.5 0.8 0.0 0.0 70.3 90.1 1.80 1.58 26.25 14.25
± SEM                         0.38 0.33 5.60 3.88
 
Test Chemical N-Nitrosomorpholine 
750         
 631 50 24 17 5 0 0 0 92 138 2.76 2.42 50.00 36.00
    634 50 27 17 3 2 0 0 108 157 3.14 2.76 62.00 44.00
    638 50 39 40 3 2 0 0 120 204 4.08 3.24 62.00 48.00
    639 50 79 19 3 1 0 0 11 113 2.26 1.86 74.00 62.00
    872 50 15 15 1 0 0 0 1 32 0.64 0.34 36.00 24.00
    874 50 31 18 3 0 0 0 5 57 1.14 0.78 50.00 34.00
    878 50 16 5 0 0 0 0 1 22 0.44 0.34 32.00 24.00
    890 50 25 17 0 0 0 0 1 43 0.86 0.52 42.00 34.00
Average         32.0 18.5 2.3 0.6 0.0 0.0 42.4 95.8 1.92 1.53 51.00 38.25
± SEM                         0.47 0.42 5.07 4.51
 
Test Chemical N-Nitrosomorpholine 
1500         
 641 50 20 18 4 0 0 0 130 172 3.44 3.08 46.00 28.00
    642 50 40 22 4 3 0 0 10 79 1.58 1.08 52.00 40.00
    643 50 64 32 6 0 0 0 82 184 3.68 3.04 64.00 52.00
    645 50 22 15 2 2 0 0 80 121 2.42 2.08 36.00 36.00
    646 50 48 17 4 0 0 0 74 143 2.86 2.52 56.00 46.00
    647 50 19 16 1 1 0 0 68 105 2.10 1.76 44.00 22.00
    648 50 30 24 2 0 0 0 53 109 2.18 1.70 56.00 42.00
    650 50 53 9 1 2 0 0 2 67 1.34 1.12 70.00 64.00
Average         37.0 19.1 3.0 1.0 0.0 0.0 62.4 122.5 2.45 2.05 53.00 41.25
± SEM                         0.29 0.28 3.89 4.69
 
Vehicle Control No Stressor 
 0         
 617 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    619 50 0 0 0 0 0 0 3 3 0.06 0.06 0.00 0.00
    867 50 0 3 0 0 0 0 0 3 0.06 0.00 4.00 0.00
    868 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    875 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    881 50 0 1 0 1 0 0 0 2 0.04 0.00 2.00 0.00
    883 50 0 1 0 0 0 0 1 2 0.04 0.02 2.00 0.00
    897 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.1 0.8 0.0 0.1 0.0 0.0 0.6 1.6 0.03 0.02 1.50 0.25
± SEM                         0.01 0.01 0.63 0.25
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation