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Study Information
Study Attribute Value
CEBS Accession Number: 002-02563-0005-0000-3
Chemical Name: N-Nitrosomorpholine
CASRN: 59-89-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 958084_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
06/13/1989 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 12175 50 2 1 0 1 0 0 0 4 0.08 0.04 8.00 4.00
    12184 50 7 3 1 0 0 0 0 11 0.22 0.16 22.00 16.00
    12204 50 9 5 0 0 0 0 0 14 0.28 0.18 24.00 16.00
    12211 50 2 2 0 0 0 0 1 5 0.10 0.06 8.00 4.00
    12220 50 8 3 0 0 0 0 1 12 0.24 0.18 22.00 18.00
    12232 50 10 2 0 0 0 0 1 13 0.26 0.22 18.00 14.00
    12236 50 13 2 0 0 0 0 2 17 0.34 0.30 20.00 18.00
    12238 50 4 3 3 0 1 0 1 12 0.24 0.18 16.00 14.00
Average         6.9 2.6 0.5 0.1 0.1 0.0 0.8 11.0 0.22 0.17 17.25 13.00
± SEM                         0.03 0.03 2.20 2.04
 
Test Chemical N-Nitrosomorpholine 
50         
 12177 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12183 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    12189 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12193 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12200 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12201 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12207 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         0.7 0.7 0.0 0.0 0.0 0.0 0.0 1.4 0.03 0.01 2.86 1.43
± SEM                         0.01 0.00 0.59 0.37
 
Test Chemical N-Nitrosomorpholine 
100         
 12170 50 1 3 0 0 0 0 1 5 0.10 0.04 6.00 2.00
    12176 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12185 50 0 1 0 0 0 0 3 4 0.08 0.06 2.00 0.00
    12186 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12187 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    12191 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12194 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12195 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.4 0.8 0.0 0.0 0.0 0.0 0.6 1.8 0.04 0.02 2.00 0.75
± SEM                         0.01 0.01 0.76 0.37
 
Test Chemical N-Nitrosomorpholine 
200         
 12168 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12169 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12172 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12173 50 1 1 0 0 0 0 1 3 0.06 0.04 4.00 2.00
    12178 50 1 1 1 0 0 0 0 3 0.06 0.04 6.00 4.00
    12180 50 1 0 0 0 0 0 1 2 0.04 0.04 2.00 2.00
    12188 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12197 50 4 0 1 0 0 0 1 6 0.12 0.12 12.00 12.00
Average         1.3 0.6 0.3 0.0 0.0 0.0 0.4 2.5 0.05 0.04 4.50 3.25
± SEM                         0.01 0.01 1.24 1.31
 
Vehicle Control No Stressor 
 0         
 12181 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    12190 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12202 50 0 1 0 0 0 0 20 21 0.42 0.40 8.00 6.00
    12206 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12217 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12231 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12235 50 1 2 1 0 0 0 0 4 0.08 0.04 6.00 4.00
    12242 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.3 0.5 0.1 0.0 0.0 0.0 2.6 3.5 0.07 0.06 2.25 1.50
± SEM                         0.05 0.05 1.10 0.82
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation