COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01970-0013-0000-3
Chemical Name: Di(2-ethylhexyl)adipate
CASRN: 103-23-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 959525_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/09/1988 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
50         
 9375 50 17 7 0 0 0 0 1 25 0.50 0.36 20.00 14.00
    9381 50 24 9 1 0 0 0 0 34 0.68 0.50 22.00 12.00
    9391 50 4 7 0 1 0 0 0 12 0.24 0.08 22.00 8.00
    9398 50 40 12 0 0 0 2 0 54 1.08 0.84 38.00 20.00
    9404 50 21 12 0 0 0 0 0 33 0.66 0.42 32.00 20.00
    9410 50 20 16 0 0 0 0 0 36 0.72 0.40 36.00 22.00
    9435 50 16 6 0 0 0 0 0 22 0.44 0.32 22.00 14.00
    9451 50 59 8 0 0 0 0 0 67 1.34 1.18 34.00 26.00
Average         25.1 9.6 0.1 0.1 0.0 0.3 0.1 35.4 0.71 0.51 28.25 17.00
± SEM                         0.13 0.12 2.63 2.10
 
Test Chemical Di(2-ethylhexyl)adipate 
1250         
 9405 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9407 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    9408 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    9417 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9418 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9427 50 0 1 0 0 0 0 2 3 0.06 0.04 2.00 0.00
    9428 50 2 2 0 0 0 0 1 5 0.10 0.06 8.00 4.00
    9432 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
Average         0.9 1.0 0.0 0.0 0.0 0.0 0.4 2.3 0.05 0.03 3.75 1.75
± SEM                         0.01 0.01 1.03 0.45
 
Test Chemical Di(2-ethylhexyl)adipate 
2500         
 9400 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    9406 50 4 3 0 1 0 0 0 8 0.16 0.08 16.00 8.00
    9411 50 2 1 0 0 0 0 1 4 0.08 0.06 6.00 4.00
    9415 50 1 3 0 0 0 0 0 4 0.08 0.02 6.00 2.00
    9416 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    9419 50 3 4 0 0 0 0 0 7 0.14 0.06 12.00 6.00
    9420 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    9430 50 0 1 0 0 0 0 1 2 0.04 0.02 2.00 0.00
Average         1.5 1.8 0.0 0.1 0.0 0.0 0.4 3.8 0.08 0.04 6.25 3.00
± SEM                         0.02 0.01 1.87 1.07
 
Test Chemical Di(2-ethylhexyl)adipate 
5000         
 9401 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    9402 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9403 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 4.00
    9413 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9421 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    9422 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    9423 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9424 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
Average         0.8 1.0 0.0 0.0 0.0 0.0 0.0 1.8 0.04 0.02 3.25 1.50
± SEM                         0.01 0.01 0.84 0.63
 
Vehicle Control No Stressor 
 0         
 9365 50 1 2 0 0 0 0 1 4 0.08 0.04 6.00 2.00
    9374 50 1 3 0 0 0 0 0 4 0.08 0.02 6.00 2.00
    9378 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    9409 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    9412 50 2 1 0 0 0 0 1 4 0.08 0.06 6.00 4.00
    9429 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9438 50 0 5 0 1 0 0 0 6 0.12 0.00 8.00 0.00
    9455 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 6.00
Average         1.4 1.6 0.0 0.1 0.0 0.0 0.3 3.4 0.07 0.03 5.25 2.75
± SEM                         0.01 0.01 0.65 0.75
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation