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Study Information
Study Attribute Value
CEBS Accession Number: 002-01970-0013-0000-3
Chemical Name: Di(2-ethylhexyl)adipate
CASRN: 103-23-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 959525_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
09/29/1988 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 10092 50 8 6 0 0 0 0 0 14 0.28 0.16 26.00 14.00
    10094 50 3 8 0 0 0 0 1 12 0.24 0.08 14.00 6.00
    10102 50 5 6 0 0 0 0 1 12 0.24 0.12 16.00 8.00
    10109 50 8 4 0 1 0 0 0 13 0.26 0.16 20.00 12.00
    10120 50 11 7 0 0 0 0 0 18 0.36 0.22 24.00 18.00
    10127 50 3 3 0 0 0 0 0 6 0.12 0.06 10.00 4.00
    10143 50 10 7 0 0 0 0 1 18 0.36 0.22 24.00 12.00
    10167 50 5 5 0 0 0 0 0 10 0.20 0.10 18.00 10.00
Average         6.6 5.8 0.0 0.1 0.0 0.0 0.4 12.9 0.26 0.14 19.00 10.50
± SEM                         0.03 0.02 1.96 1.59
 
Test Chemical Di(2-ethylhexyl)adipate 
1250         
 10131 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10135 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    10137 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    10140 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    10141 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10147 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10164 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10168 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         0.8 1.1 0.0 0.0 0.0 0.0 0.0 1.9 0.04 0.02 3.75 1.50
± SEM                         0.01 0.01 0.88 0.63
 
Test Chemical Di(2-ethylhexyl)adipate 
2500         
 10134 50 1 1 0 1 0 0 0 3 0.06 0.02 6.00 2.00
    10142 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10144 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    10145 50 2 2 0 0 0 0 0 4 0.08 0.04 4.00 2.00
    10146 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10149 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    10160 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10165 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         1.1 1.3 0.0 0.1 0.0 0.0 0.0 2.5 0.05 0.02 4.50 2.00
± SEM                         0.01 0.00 0.73 0.38
 
Test Chemical Di(2-ethylhexyl)adipate 
5000         
 10136 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10138 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10153 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10154 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10155 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10162 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 4.00
    10166 50 3 4 0 0 0 0 0 7 0.14 0.06 8.00 4.00
    10169 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
Average         1.1 1.4 0.0 0.0 0.0 0.0 0.0 2.5 0.05 0.02 4.00 2.00
± SEM                         0.01 0.01 0.85 0.53
 
Vehicle Control No Stressor 
 0         
 10085 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    10095 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10107 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10110 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10112 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    10116 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 4.00
    10150 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10159 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.6 1.1 0.0 0.0 0.0 0.0 0.0 1.8 0.04 0.01 3.25 1.25
± SEM                         0.01 0.01 1.00 0.65
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation