| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02064-0011-0000-6 |
| Chemical Name: | Dimethyl morpholinophosphoramidate |
| CASRN: | 597-25-1 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 963445_SCE |
| Study Result: | Not a Valid Test |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 08/29/1989 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Equivocal |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
12961 | 25 | 4.24 | ± | 0.308 |
| 12968 | 25 | 4.93 | ± | 0.515 | |||
| 12971 | 25 | 5.64 | ± | 0.643 | |||
| 12979 | 25 | 4.78 | ± | 0.297 | |||
| Average | 4.90 | ± | 0.289 | ||||
| Test Chemical | Dimethyl morpholinophosphoramidate |
2000 |
12976 | 25 | 6.69 | ± | 0.509 |
| 12982 | 25 | 4.73 | ± | 0.455 | |||
| 12983 | 25 | 4.55 | ± | 0.299 | |||
| Average | 5.32 | ± | 0.684 | ||||
| Test Chemical | Dimethyl morpholinophosphoramidate |
4000 |
12964 | 25 | 6.40 | ± | 0.658 |
| 12965 | 25 | 6.48 | ± | 0.477 | |||
| 12966 | 25 | 5.60 | ± | 0.597 | |||
| 12978 | 25 | 5.07 | ± | 0.470 | |||
| Average | 5.89 | ± | 0.337 | ||||
| Positive Control | Mitomycin-C |
0.5 |
12960 | 25 | 7.87 | ± | 0.634 |
| 12962 | 25 | 10.92 | ± | 0.744 | |||
| 12972 | 25 | 12.70 | ± | 1.009 | |||
| 12973 | 25 | 10.41 | ± | 0.624 | |||
| Average | 10.48 | ± | 0.996 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed