COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02064-0012-0000-7
Chemical Name: Dimethyl morpholinophosphoramidate
CASRN: 597-25-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 963455_CA
Study Result: Negative (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/22/1989 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative (Nonstandard Protocol)

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 12839 50 2 2 0 0 0 0 3 7 0.14 0.10 14.00 10.00
    12843 50 5 2 1 0 0 0 2 10 0.20 0.16 18.00 14.00
    12859 50 5 1 0 0 0 0 2 8 0.16 0.14 14.00 12.00
    12862 50 5 1 0 0 0 0 3 9 0.18 0.16 16.00 16.00
    12875 50 4 1 0 0 0 0 1 6 0.12 0.10 8.00 6.00
    12881 50 7 3 1 0 0 0 1 12 0.24 0.18 20.00 16.00
    12895 50 4 4 0 0 0 0 2 10 0.20 0.12 16.00 8.00
    12899 50 3 1 0 0 0 1 2 7 0.14 0.12 10.00 8.00
Average         4.4 1.9 0.3 0.0 0.0 0.1 2.0 8.6 0.17 0.14 14.50 11.25
± SEM                         0.01 0.01 1.40 1.36
 
Test Chemical Dimethyl morpholinophosphoramidate 
2000         
 12877 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    12880 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    12882 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    12887 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12891 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12894 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    12900 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    12905 50 2 1 0 0 0 0 1 4 0.08 0.06 6.00 4.00
Average         1.0 0.9 0.0 0.0 0.0 0.0 0.3 2.1 0.04 0.03 3.50 2.00
± SEM                         0.01 0.01 0.73 0.65
 
Test Chemical Dimethyl morpholinophosphoramidate 
4000         
 12883 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    12884 50 1 2 0 0 0 0 1 4 0.08 0.04 6.00 2.00
    12885 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12889 50 1 2 0 1 0 0 0 4 0.08 0.02 8.00 2.00
    12893 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12896 50 1 1 0 0 0 0 2 4 0.08 0.06 4.00 2.00
    12901 50 1 0 0 0 0 0 1 2 0.04 0.04 2.00 2.00
    12906 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
Average         1.0 1.0 0.0 0.1 0.0 0.0 0.6 2.8 0.06 0.03 4.25 2.00
± SEM                         0.01 0.01 1.03 0.38
 
Vehicle Control No Stressor 
 0         
 12841 50 0 1 0 0 0 0 1 2 0.04 0.02 2.00 0.00
    12854 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    12866 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12867 50 2 0 0 0 0 0 1 3 0.06 0.06 4.00 4.00
    12886 50 4 1 0 0 0 0 0 5 0.10 0.08 4.00 2.00
    12902 50 3 3 0 0 0 0 0 6 0.12 0.06 10.00 6.00
    12903 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12904 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         1.6 0.9 0.0 0.0 0.0 0.0 0.3 2.8 0.06 0.04 4.00 2.50
± SEM                         0.01 0.01 1.07 0.91
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation