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Study Information
Study Attribute Value
CEBS Accession Number: 002-01494-0012-0000-3
Chemical Name: 4-Chloro-o-phenylenediamine
CASRN: 95-83-0
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 970086_CA
Study Result: Positive (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
06/28/1984 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive (Nonstandard Protocol)

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
200         
 1633 50 5 4 0 0 0 0 1 10 0.20 0.12 16.00 10.00
    1634 50 7 5 1 0 0 0 0 13 0.26 0.16 18.00 12.00
    1635 50 12 0 1 0 0 0 1 14 0.28 0.28 24.00 24.00
    1636 50 19 1 1 0 0 0 2 23 0.46 0.44 24.00 24.00
    1637 50 10 5 1 0 0 0 0 16 0.32 0.22 14.00 10.00
    1638 50 20 12 0 0 0 0 11 43 0.86 0.62 40.00 36.00
    1639 50 10 4 0 0 0 0 1 15 0.30 0.22 24.00 20.00
    1640 50 6 12 1 0 0 0 0 19 0.38 0.14 28.00 14.00
Average         11.1 5.4 0.6 0.0 0.0 0.0 2.0 19.1 0.38 0.28 23.50 18.75
± SEM                         0.07 0.06 2.90 3.21
 
Test Chemical 4-Chloro-o-phenylenediamine 
100         
 1641 50 5 1 1 0 0 0 0 7 0.14 0.12 6.00 6.00
    1642 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1643 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1644 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1645 50 3 0 0 0 0 0 0 3 0.06 0.06 14.00 14.00
    1646 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 4.00
    1647 50 1 1 0 0 0 0 0 2 0.04 0.02 6.00 4.00
    1648 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.6 0.4 0.1 0.0 0.0 0.0 0.0 2.1 0.04 0.04 4.25 3.75
± SEM                         0.02 0.02 1.71 1.67
 
Test Chemical 4-Chloro-o-phenylenediamine 
200         
 1649 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 4.00
    1650 50 7 1 1 0 0 0 0 9 0.18 0.16 18.00 18.00
    1651 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1652 50 1 0 0 0 0 0 0 1 0.02 0.02 6.00 6.00
    1653 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1654 50 0 0 1 0 0 0 0 1 0.02 0.02 18.00 18.00
    1655 50 0 0 0 0 0 0 0 0 0.00 0.00 28.00 28.00
    1656 50 0 0 0 0 0 0 0 0 0.00 0.00 2.00 2.00
Average         1.1 0.4 0.3 0.0 0.0 0.0 0.0 1.8 0.04 0.03 9.75 9.50
± SEM                         0.02 0.02 3.65 3.70
 
Test Chemical 4-Chloro-o-phenylenediamine 
400         
 1657 50 2 0 0 0 0 0 1 3 0.06 0.06 22.00 22.00
    1658 50 2 0 0 0 0 0 0 2 0.04 0.04 6.00 6.00
    1659 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1660 50 1 0 0 0 0 0 0 1 0.02 0.02 6.00 6.00
    1661 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    1662 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    1663 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
    1664 50 8 0 3 0 0 0 0 11 0.22 0.22 20.00 20.00
Average         2.4 0.3 0.4 0.0 0.0 0.0 0.1 3.1 0.06 0.06 8.75 8.25
± SEM                         0.02 0.02 2.78 2.94
 
Vehicle Control No Stressor 
 0         
 1715 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1716 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1717 50 3 0 1 0 0 0 1 5 0.10 0.10 10.00 10.00
    1718 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1719 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    1720 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1721 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1722 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.8 0.0 0.1 0.0 0.0 0.0 0.1 1.0 0.02 0.02 2.00 2.00
± SEM                         0.01 0.01 1.25 1.25
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation