| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01494-0011-0000-2 |
| Chemical Name: | 4-Chloro-o-phenylenediamine |
| CASRN: | 95-83-0 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 970086_SCE |
| Study Result: | Negative (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 06/12/1984 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative (Nonstandard Protocol) |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
1591 | 25 | 4.73 | ± | 0.578 |
| 1592 | 25 | 5.65 | ± | 0.572 | |||
| 1593 | 25 | 5.26 | ± | 0.414 | |||
| 1594 | 25 | 5.40 | ± | 0.512 | |||
| 1596 | 25 | 3.89 | ± | 0.473 | |||
| 1597 | 25 | 3.50 | ± | 0.511 | |||
| 1598 | 25 | 4.06 | ± | 0.396 | |||
| 1599 | 25 | 6.41 | ± | 1.051 | |||
| Average | 4.87 | ± | 0.351 | ||||
| Test Chemical | 4-Chloro-o-phenylenediamine |
100 |
1561 | 25 | 6.30 | ± | 0.720 |
| 1562 | 25 | 6.25 | ± | 0.632 | |||
| 1563 | 25 | 4.03 | ± | 0.524 | |||
| 1564 | 25 | 5.83 | ± | 0.577 | |||
| Average | 5.61 | ± | 0.535 | ||||
| Test Chemical | 4-Chloro-o-phenylenediamine |
200 |
1566 | 25 | 4.94 | ± | 0.644 |
| 1567 | 25 | 5.56 | ± | 0.766 | |||
| 1568 | 25 | 6.06 | ± | 0.529 | |||
| 1569 | 25 | 4.10 | ± | 0.442 | |||
| Average | 5.17 | ± | 0.424 | ||||
| Test Chemical | 4-Chloro-o-phenylenediamine |
400 |
1571 | 25 | 8.07 | ± | 0.836 |
| 1572 | 25 | 5.87 | ± | 0.612 | |||
| 1573 | 25 | 4.36 | ± | 0.526 | |||
| 1574 | 25 | 5.05 | ± | 0.453 | |||
| Average | 5.84 | ± | 0.806 | ||||
| Positive Control | Dimethylbenzanthracene |
10 |
1536 | 25 | 12.68 | ± | 1.404 |
| 1537 | 25 | 10.42 | ± | 0.803 | |||
| 1538 | 25 | 10.91 | ± | 1.173 | |||
| 1539 | 25 | 14.17 | ± | 1.233 | |||
| 1541 | 25 | 14.47 | ± | 1.040 | |||
| 1542 | 25 | 10.12 | ± | 0.754 | |||
| 1543 | 25 | 13.22 | ± | 1.336 | |||
| 1544 | 25 | 13.34 | ± | 1.011 | |||
| Average | 12.41 | ± | 0.603 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed