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Study Information
Study Attribute Value
CEBS Accession Number: 002-02194-0017-0000-6
Chemical Name: Furfural
CASRN: 98-01-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 991433_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
02/19/1987 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 4762 50 5 2 1 0 0 0 0 8 0.16 0.12 16.00 12.00
    4782 50 4 2 0 0 0 1 1 8 0.16 0.12 12.00 10.00
    4795 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4799 50 0 0 0 0 0 0 2 2 0.04 0.04 4.00 4.00
    4813 50 4 3 0 0 0 0 0 7 0.14 0.08 12.00 8.00
    4818 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4820 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    4839 50 4 3 0 0 0 0 1 8 0.16 0.10 14.00 10.00
Average         2.4 1.5 0.1 0.0 0.0 0.1 0.5 4.6 0.09 0.06 8.25 6.00
± SEM                         0.02 0.02 2.05 1.60
 
Test Chemical Furfural 
50         
 4765 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4779 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4781 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4784 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4807 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4811 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4836 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4841 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         0.4 0.4 0.0 0.0 0.0 0.0 0.0 0.8 0.02 0.01 1.50 0.75
± SEM                         0.01 0.00 0.50 0.37
 
Test Chemical Furfural 
100         
 4764 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4769 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4770 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4776 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4783 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4787 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    4814 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4823 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.4 0.3 0.0 0.0 0.0 0.0 0.0 0.6 0.01 0.01 1.25 0.75
± SEM                         0.01 0.01 0.53 0.53
 
Test Chemical Furfural 
200         
 4767 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4771 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4774 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 4.00
    4793 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4794 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4810 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4819 50 0 1 1 0 0 0 0 2 0.04 0.02 4.00 2.00
    4830 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.8 0.1 0.0 0.0 0.0 0.0 1.4 0.03 0.01 2.50 1.25
± SEM                         0.01 0.01 0.63 0.53
 
Vehicle Control No Stressor 
 0         
 4773 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    4780 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 4.00
    4792 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4797 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4808 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    4817 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4827 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    4835 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         1.3 0.4 0.0 0.0 0.0 0.0 0.0 1.6 0.03 0.03 3.25 2.75
± SEM                         0.01 0.01 0.65 0.65
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation