COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02194-0017-0000-6
Chemical Name: Furfural
CASRN: 98-01-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 991433_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
10/27/1987 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 6455 50 3 2 0 0 0 0 0 5 0.10 0.06 10.00 6.00
    6457 50 1 3 1 0 0 0 1 6 0.12 0.06 10.00 4.00
    6476 50 4 1 0 0 0 0 0 5 0.10 0.08 8.00 6.00
    6481 50 13 0 0 0 0 0 0 13 0.26 0.26 16.00 16.00
    6486 50 7 4 1 0 0 1 0 13 0.26 0.18 28.00 20.00
    6491 50 3 1 0 0 0 0 2 6 0.12 0.10 12.00 10.00
    6492 50 8 2 0 0 0 0 0 10 0.20 0.16 12.00 10.00
    6493 50 15 1 0 0 0 0 0 16 0.32 0.30 12.00 10.00
Average         6.8 1.8 0.3 0.0 0.0 0.1 0.4 9.3 0.19 0.15 13.50 10.25
± SEM                         0.03 0.03 2.23 1.91
 
Test Chemical Furfural 
50         
 6454 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6461 50 2 0 0 0 0 0 1 3 0.06 0.06 4.00 4.00
    6462 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6471 50 5 2 0 0 0 0 0 7 0.14 0.10 12.00 10.00
    6475 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6488 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    6489 50 1 1 0 0 0 0 1 3 0.06 0.04 4.00 2.00
    6500 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
Average         1.5 0.4 0.0 0.0 0.0 0.0 0.4 2.3 0.05 0.04 3.50 3.00
± SEM                         0.02 0.01 1.59 1.41
 
Test Chemical Furfural 
100         
 6456 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6458 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    6465 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    6474 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    6482 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6484 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6490 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6497 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.3 0.0 0.0 0.0 0.0 0.1 0.9 0.02 0.01 1.50 1.00
± SEM                         0.00 0.00 0.50 0.38
 
Test Chemical Furfural 
200         
 6460 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    6464 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6470 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6473 50 0 0 0 0 0 0 2 2 0.04 0.04 0.00 0.00
    6480 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    6485 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6487 50 1 1 0 0 0 0 1 3 0.06 0.04 4.00 2.00
    6495 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
Average         0.6 0.5 0.0 0.0 0.0 0.0 0.4 1.5 0.03 0.02 2.25 1.25
± SEM                         0.01 0.01 0.88 0.53
 
Vehicle Control No Stressor 
 0         
 6459 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6467 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    6472 50 0 0 0 0 0 0 0 0 0.00 0.00 2.00 2.00
    6477 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6483 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6494 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6496 50 2 0 0 0 0 0 1 3 0.06 0.06 4.00 4.00
    6499 50 2 1 0 0 0 0 0 3 0.06 0.04 2.00 2.00
Average         0.8 0.3 0.0 0.0 0.0 0.0 0.1 1.1 0.02 0.02 1.75 1.50
± SEM                         0.01 0.01 0.59 0.50
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation