| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02194-0016-0000-5 |
| Chemical Name: | Furfural |
| CASRN: | 98-01-1 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 991433_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 02/12/1987 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
4712 | 23 | 3.59 | ± | 0.452 |
| 4727 | 24 | 4.32 | ± | 0.440 | |||
| 4732 | 25 | 4.43 | ± | 0.378 | |||
| 4743 | 23 | 3.67 | ± | 0.727 | |||
| Average | 4.02 | ± | 0.216 | ||||
| Test Chemical | Furfural |
50 |
4721 | 25 | 4.79 | ± | 0.385 |
| 4729 | 25 | 4.35 | ± | 0.433 | |||
| 4737 | 25 | 6.17 | ± | 0.624 | |||
| 4738 | 24 | 4.00 | ± | 0.430 | |||
| Average | 4.84 | ± | 0.477 | ||||
| Test Chemical | Furfural |
100 |
4711 | 23 | 2.95 | ± | 0.320 |
| 4728 | 25 | 4.59 | ± | 0.380 | |||
| 4730 | 25 | 2.97 | ± | 0.309 | |||
| 4750 | 24 | 3.21 | ± | 0.334 | |||
| Average | 3.44 | ± | 0.392 | ||||
| Test Chemical | Furfural |
200 |
4723 | 25 | 4.37 | ± | 0.463 |
| 4733 | 24 | 3.68 | ± | 0.416 | |||
| 4736 | 25 | 3.73 | ± | 0.476 | |||
| 4747 | 25 | 4.91 | ± | 0.503 | |||
| Average | 4.18 | ± | 0.291 | ||||
| Positive Control | Mitomycin-C |
0.5 |
4708 | 25 | 6.23 | ± | 0.658 |
| 4742 | 25 | 6.31 | ± | 0.690 | |||
| 4744 | 25 | 7.73 | ± | 0.763 | |||
| 4758 | 25 | 8.18 | ± | 0.512 | |||
| Average | 7.11 | ± | 0.494 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed