| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02194-0016-0000-5 |
| Chemical Name: | Furfural |
| CASRN: | 98-01-1 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 991433_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 08/18/1987 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
5965 | 25 | 3.36 | ± | 0.347 |
| 5978 | 25 | 6.46 | ± | 0.654 | |||
| 5992 | 24 | 5.70 | ± | 0.570 | |||
| Average | 5.17 | ± | 0.932 | ||||
| Test Chemical | Furfural |
50 |
5953 | 25 | 5.09 | ± | 0.427 |
| 5960 | 25 | 3.84 | ± | 0.323 | |||
| 5967 | 25 | 4.17 | ± | 0.350 | |||
| 5981 | 25 | 4.10 | ± | 0.361 | |||
| Average | 4.30 | ± | 0.273 | ||||
| Test Chemical | Furfural |
100 |
5949 | 25 | 2.95 | ± | 0.298 |
| 5972 | 25 | 3.65 | ± | 0.308 | |||
| 5996 | 25 | 4.34 | ± | 0.439 | |||
| 6014 | 24 | 4.42 | ± | 0.420 | |||
| Average | 3.83 | ± | 0.343 | ||||
| Test Chemical | Furfural |
200 |
5963 | 25 | 4.79 | ± | 0.511 |
| 5970 | 24 | 3.32 | ± | 0.348 | |||
| 6005 | 25 | 4.26 | ± | 0.391 | |||
| 6013 | 25 | 3.78 | ± | 0.386 | |||
| Average | 4.05 | ± | 0.315 | ||||
| Positive Control | Mitomycin-C |
0.5 |
5946 | 24 | 4.42 | ± | 0.421 |
| 5975 | 24 | 3.83 | ± | 0.360 | |||
| 6000 | 23 | 3.80 | ± | 0.477 | |||
| 6017 | 25 | 3.91 | ± | 0.345 | |||
| Average | 4.00 | ± | 0.145 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed