COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01984-0014-0000-9
Chemical Name: Diallyl phthalate
CASRN: 131-17-9
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 993263_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
11/28/1988 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 9168 50 5 3 1 0 0 0 0 9 0.18 0.12 12.00 8.00
    9169 50 14 4 0 0 0 0 0 18 0.36 0.28 24.00 18.00
    9170 50 8 9 0 0 0 0 0 17 0.34 0.16 20.00 12.00
    9171 50 10 3 0 0 0 0 0 13 0.26 0.20 18.00 16.00
    9172 50 15 2 0 0 0 0 0 17 0.34 0.30 26.00 24.00
    9173 50 15 4 0 0 0 0 0 19 0.38 0.30 10.00 6.00
    9174 50 11 6 0 0 0 0 0 17 0.34 0.22 22.00 18.00
    9175 50 8 3 0 0 0 0 0 11 0.22 0.16 16.00 12.00
Average         10.8 4.3 0.1 0.0 0.0 0.0 0.0 15.1 0.30 0.22 18.50 14.25
± SEM                         0.03 0.02 1.99 2.09
 
Test Chemical Diallyl phthalate 
75         
 9098 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 4.00
    9099 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    9100 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
    9101 50 7 3 0 0 0 0 0 10 0.20 0.14 14.00 10.00
    9102 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    9103 50 6 0 0 0 0 0 0 6 0.12 0.12 12.00 12.00
    9104 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    9105 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         3.6 0.6 0.0 0.0 0.0 0.0 0.0 4.3 0.09 0.07 7.50 6.50
± SEM                         0.02 0.01 1.40 1.18
 
Test Chemical Diallyl phthalate 
150         
 9108 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    9109 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9110 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9111 50 4 0 0 0 0 0 0 4 0.08 0.08 6.00 6.00
    9112 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9113 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    9114 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9115 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         1.5 0.3 0.0 0.0 0.0 0.0 0.0 1.8 0.04 0.03 3.25 2.75
± SEM                         0.01 0.01 0.92 0.84
 
Test Chemical Diallyl phthalate 
300         
 9118 50 6 2 0 0 0 0 0 8 0.16 0.12 14.00 12.00
    9119 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    9120 50 3 2 0 0 0 0 0 5 0.10 0.06 8.00 6.00
    9121 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
    9122 50 5 2 1 0 0 0 0 8 0.16 0.12 12.00 10.00
    9123 50 6 3 0 0 0 0 0 9 0.18 0.12 14.00 8.00
    9124 50 5 3 0 0 0 0 0 8 0.16 0.10 14.00 10.00
    9125 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
Average         4.0 1.8 0.1 0.0 0.0 0.0 0.0 5.9 0.12 0.08 10.00 7.50
± SEM                         0.02 0.01 1.41 1.18
 
Vehicle Control No Stressor 
 0         
 9158 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    9159 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9160 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    9161 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    9162 50 5 1 0 1 0 0 0 7 0.14 0.10 14.00 10.00
    9163 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9164 50 2 1 0 0 0 0 0 3 0.06 0.04 8.00 6.00
    9165 50 1 0 0 1 0 0 0 2 0.04 0.02 4.00 2.00
Average         1.5 0.9 0.0 0.3 0.0 0.0 0.0 2.6 0.05 0.03 5.50 3.25
± SEM                         0.01 0.01 1.50 1.25
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation