Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01984-0014-0000-9 |
Chemical Name: | Diallyl phthalate |
CASRN: | 131-17-9 |
NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
NTP Study ID: | 993263_CA |
Study Result: | Positive |
Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.
Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Result |
---|---|---|---|---|---|---|---|
08/28/1989 | Bone Marrow | 17 | Male | Mouse | B6C3F1 | Intraperitoneal Injection x 1/study, 17 hour | Positive |
Dose (mg/kg) |
Animal Number |
No. Cells |
Chromatid | Isochromatid | Exchanges | Aberrations | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Breaks | Gaps | Breaks | Gaps | 'Tid | 'Some | Other | Total | Per Cell | % Cells w/ Abs | |||||||
(+ Gaps) | (- Gaps) | (+ Gaps) | (- Gaps) | |||||||||||||
Positive Control | Dimethylbenzanthracene |
50 |
10420 | 50 | 7 | 4 | 0 | 0 | 0 | 0 | 0 | 11 | 0.22 | 0.14 | 14.00 | 8.00 |
10421 | 50 | 15 | 2 | 0 | 0 | 0 | 0 | 0 | 17 | 0.34 | 0.30 | 24.00 | 22.00 | |||
10422 | 50 | 5 | 3 | 0 | 0 | 0 | 0 | 0 | 8 | 0.16 | 0.10 | 14.00 | 10.00 | |||
10423 | 50 | 7 | 5 | 0 | 1 | 0 | 0 | 0 | 13 | 0.26 | 0.14 | 18.00 | 12.00 | |||
10424 | 50 | 5 | 3 | 0 | 0 | 0 | 0 | 0 | 8 | 0.16 | 0.10 | 16.00 | 10.00 | |||
10425 | 50 | 7 | 3 | 1 | 0 | 0 | 0 | 0 | 11 | 0.22 | 0.16 | 14.00 | 12.00 | |||
10426 | 50 | 8 | 3 | 0 | 0 | 0 | 0 | 0 | 11 | 0.22 | 0.16 | 14.00 | 12.00 | |||
10427 | 50 | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 6 | 0.12 | 0.08 | 8.00 | 6.00 | |||
Average | 7.3 | 3.1 | 0.1 | 0.1 | 0.0 | 0.0 | 0.0 | 10.6 | 0.21 | 0.15 | 15.25 | 11.50 | ||||
± SEM | 0.02 | 0.02 | 1.60 | 1.68 | ||||||||||||
Test Chemical | Diallyl phthalate |
75 |
10352 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 |
10353 | 50 | 1 | 0 | 2 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.06 | 6.00 | 6.00 | |||
10354 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
10355 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
10356 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
10357 | 50 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.04 | 4.00 | 4.00 | |||
10358 | 50 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 4 | 0.08 | 0.04 | 8.00 | 4.00 | |||
10359 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
Average | 0.9 | 0.3 | 0.3 | 0.0 | 0.0 | 0.0 | 0.0 | 1.4 | 0.03 | 0.02 | 2.75 | 2.25 | ||||
± SEM | 0.01 | 0.01 | 1.06 | 0.80 | ||||||||||||
Test Chemical | Diallyl phthalate |
150 |
10360 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 |
10361 | 50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.02 | 6.00 | 4.00 | |||
10362 | 50 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.04 | 4.00 | 4.00 | |||
10363 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
10364 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
10365 | 50 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.04 | 4.00 | 4.00 | |||
10366 | 50 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.04 | 4.00 | 4.00 | |||
10367 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
Average | 0.8 | 0.1 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 1.0 | 0.02 | 0.02 | 2.25 | 2.00 | ||||
± SEM | 0.01 | 0.01 | 0.88 | 0.76 | ||||||||||||
Test Chemical | Diallyl phthalate |
300 |
10370 | 50 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.06 | 6.00 | 6.00 |
10371 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
10372 | 50 | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 6 | 0.12 | 0.08 | 12.00 | 8.00 | |||
10373 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
10374 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
10376 | 50 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.04 | 6.00 | 4.00 | |||
10377 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.00 | 2.00 | 0.00 | |||
10378 | 50 | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 5 | 0.10 | 0.08 | 8.00 | 6.00 | |||
Average | 2.0 | 0.6 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.6 | 0.05 | 0.04 | 5.00 | 3.75 | ||||
± SEM | 0.01 | 0.01 | 1.31 | 0.96 | ||||||||||||
Vehicle Control | No Stressor |
0 |
10329 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 |
10330 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
10331 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
10332 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
10334 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
10335 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
10336 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
10337 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
Average | 0.6 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.6 | 0.01 | 0.01 | 1.25 | 1.25 | ||||
± SEM | 0.00 | 0.00 | 0.37 | 0.37 | ||||||||||||
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation