| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02148-0009-0000-6 |
| Chemical Name: | Ethyl methanesulfonate |
| CASRN: | 62-50-0 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 998123_CA |
| Study Result: | Positive (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Result |
|---|---|---|---|---|---|---|---|
| 06/09/1983 | Bone Marrow | 17 | Male | Mouse | B6C3F1 | Intraperitoneal Injection x 1/study, 17 hour | Positive (Nonstandard Protocol) |
| Dose (mg/kg) |
Animal Number |
No. Cells |
Chromatid | Isochromatid | Exchanges | Aberrations | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Breaks | Gaps | Breaks | Gaps | 'Tid | 'Some | Other | Total | Per Cell | % Cells w/ Abs | |||||||
| (+ Gaps) | (- Gaps) | (+ Gaps) | (- Gaps) | |||||||||||||
| Test Chemical | Ethyl methanesulfonate |
93.75 |
1048 | 100 | 6 | 4 | 0 | 0 | 0 | 0 | 1 | 11 | 0.11 | 0.07 | 9.00 | 6.00 |
| 1049 | 100 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 4 | 0.04 | 0.03 | 4.00 | 3.00 | |||
| 1050 | 100 | 7 | 3 | 0 | 0 | 0 | 0 | 0 | 10 | 0.10 | 0.07 | 8.00 | 5.00 | |||
| 1051 | 100 | 7 | 1 | 0 | 0 | 0 | 0 | 0 | 8 | 0.08 | 0.07 | 7.00 | 6.00 | |||
| Average | 5.8 | 2.3 | 0.0 | 0.0 | 0.0 | 0.0 | 0.3 | 8.3 | 0.08 | 0.06 | 7.00 | 5.00 | ||||
| ± SEM | 0.02 | 0.01 | 1.08 | 0.71 | ||||||||||||
| Test Chemical | Ethyl methanesulfonate |
187.5 |
1052 | 100 | 4 | 0 | 0 | 0 | 0 | 0 | 1 | 5 | 0.05 | 0.05 | 5.00 | 5.00 |
| 1053 | 100 | 6 | 8 | 0 | 0 | 0 | 0 | 2 | 16 | 0.16 | 0.08 | 11.00 | 5.00 | |||
| 1054 | 100 | 6 | 0 | 1 | 0 | 1 | 0 | 0 | 8 | 0.08 | 0.08 | 8.00 | 8.00 | |||
| 1055 | 100 | 9 | 3 | 0 | 0 | 0 | 0 | 0 | 12 | 0.12 | 0.09 | 9.00 | 8.00 | |||
| Average | 6.3 | 2.8 | 0.3 | 0.0 | 0.3 | 0.0 | 0.8 | 10.3 | 0.10 | 0.08 | 8.25 | 6.50 | ||||
| ± SEM | 0.02 | 0.01 | 1.25 | 0.87 | ||||||||||||
| Test Chemical | Ethyl methanesulfonate |
375 |
1057 | 100 | 2 | 3 | 0 | 0 | 0 | 0 | 4 | 9 | 0.09 | 0.06 | 8.00 | 6.00 |
| 1058 | 100 | 4 | 2 | 0 | 0 | 1 | 0 | 1 | 8 | 0.08 | 0.06 | 7.00 | 6.00 | |||
| 1060 | 100 | 4 | 2 | 0 | 0 | 0 | 0 | 10 | 16 | 0.16 | 0.14 | 14.00 | 12.00 | |||
| 1061 | 100 | 3 | 3 | 0 | 0 | 0 | 0 | 3 | 9 | 0.09 | 0.06 | 9.00 | 6.00 | |||
| Average | 3.3 | 2.5 | 0.0 | 0.0 | 0.3 | 0.0 | 4.5 | 10.5 | 0.11 | 0.08 | 9.50 | 7.50 | ||||
| ± SEM | 0.02 | 0.02 | 1.55 | 1.50 | ||||||||||||
| Vehicle Control | No Stressor |
0 |
1062 | 100 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.01 | 0.01 | 1.00 | 1.00 |
| 1063 | 100 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0.03 | 0.03 | 2.00 | 2.00 | |||
| 1065 | 100 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.01 | 0.01 | 1.00 | 1.00 | |||
| 1066 | 100 | 3 | 1 | 1 | 0 | 1 | 0 | 1 | 7 | 0.07 | 0.06 | 5.00 | 5.00 | |||
| Average | 2.0 | 0.3 | 0.3 | 0.0 | 0.3 | 0.0 | 0.3 | 3.0 | 0.03 | 0.03 | 2.25 | 2.25 | ||||
| ± SEM | 0.01 | 0.01 | 0.95 | 0.95 | ||||||||||||
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation